Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases
Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases
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DOI：
10.1111/j.1600-0625.2006.00485.x
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发表时间：
2007-02-01
影响因子：
3.6
通讯作者：
Sato, Shinichi
中科院分区：
文献类型：
--
作者：
Matsushita, Takashi;Hasegawa, Minoru;Sato, Shinichi
属于肿瘤坏死因子家族（BAFF）的B细胞活化因子（一种有效的B细胞存活因子）的血清水平在患有系统性自身免疫性疾病（诸如系统性红斑狼疮（SLE）、类风湿性关节炎和系统性硬化症（SSc））的患者中升高。本研究的目的是确定血清BAFF水平，并将结果与皮肤器官特异性自身免疫性疾病（如局限性硬皮病和自身免疫性大疱病）患者的临床特征联系起来。采用酶联免疫吸附法检测了44例局限性硬皮病、20例寻常型天疱疮/落叶型天疱疮、20例大疱性类天疱疮和30例健康对照者血清BAFF水平。20例SSc和20例SLE患者也作为疾病对照进行了检查。与健康对照组相比，局限性硬皮病患者血清BAFF水平升高。关于局限性硬皮病亚组，全身性硬斑病（局限性硬皮病的最常见形式）患者的血清BAFF水平高于线性硬皮病或硬斑病患者。全身性硬斑病的BAFF水平与SSc或SLE的BAFF水平相当。此外，血清BAFF水平与抗组蛋白抗体水平、皮损严重程度和皮损数量呈正相关。相比之下，天疱疮或类天疱疮患者的血清BAFF水平没有显著升高。这些结果表明，BAFF可能有助于自身免疫和局限性硬皮病的疾病发展。
Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to determine serum BAFF levels and relate the results to the clinical features in patients with organ-specific autoimmune diseases of the skin, such as localized scleroderma and autoimmune bullous diseases. Serum BAFF levels were examined by enzyme-linked immunosorbent assay in 44 patients with localized scleroderma, 20 with pemphigus vulgaris/pemphigus foliaceus, 20 with bullous pemphigoid and 30 healthy controls. Twenty patients with SSc and 20 with SLE were also examined as disease controls. Serum BAFF levels were elevated in localized scleroderma patients compared with healthy controls. Concerning localized scleroderma subgroups, patients with generalized morphea, the severest form of localized scleroderma, had higher serum BAFF levels than linear scleroderma or morphea patients. The BAFF levels of generalized morphea were comparable with those of SSc or SLE. Furthermore, serum BAFF levels correlated positively with antihistone antibody levels and the severity of skin lesion as well as the number of skin lesions. By contrast, serum BAFF levels were not significantly elevated in patients with pemphigus or pemphigoid. These results suggest that BAFF may be contributing to autoimmunity and disease development in localized scleroderma.