Emerging role of circular RNAs in the pathobiology of lung cancer
Emerging role of circular RNAs in the pathobiology of lung cancer
复制标题
DOI：
10.1016/j.biopha.2021.111805
复制
发表时间：
2021-06-11
影响因子：
7.5
通讯作者：
Hajiesmaeili, Mohammadreza
中科院分区：
文献类型：
--
作者：
Ghafouri-Fard, Soudeh;Dinger, Marcel E.;Hajiesmaeili, Mohammadreza
肺癌是男女癌症死亡率和发病率的主要原因之一。不同类型的转录本已被提出作为这种类型癌症的分子标记物。环状RNA（CircRNA）是一类具有环状封闭结构的稳定转录物。这些转录物在血液中是稳定的，因此可以用作检测疾病的标记物。此外，不同癌症患者的受影响组织中circRNA的失调显示了它们在癌发生中的可能作用。已发现包括circPRKC 1、circFGFR 1、hsa-circ-0020123和circTP 63在内的几种circRNA在肺癌样本中上调。同时，与非癌对应物相比，cir-ITCH、hsa_circ_100395、hsa_circ_0033155、circRNF 13、circNOL 10、circ-UBR 5、circPTK 2和circCRIM 1已显示在肺癌组织中下调。最后，评估了circPRKC 1、circFGFR 1、has-circ-00120123、circTP 63、circ_0067934、CDR 1as、hsa_circRN_103809和其他circRNA在肺癌中的预后价值。在目前的手稿中，我们描述了circRNA在肺癌病理学中的影响和效用。
Lung cancer is among the leading causes of cancer mortality and incidence in both sexes. Different classes of transcripts have been proposed as molecular markers in this type of cancer. Circular RNAs (circRNAs) are a group of transcripts with circular enclosed and stable configuration. These transcripts are stable in the blood, thus can be used as markers for detection of disorders. Moreover, dysregulation of circRNAs in the affected tissues of patients with different cancers shows their possible roles in the carcinogenesis. Several circRNAs including circPRKC1, circFGFR1, hsa-circ-0020123 and circTP63 have been found to be up-regulated in lung cancer samples. Meanwhile, cir-ITCH, hsa_circ_100395, hsa_circ_0033155, circRNF13, circNOL10, circ-UBR5, circPTK2 and circCRIM1 have been shown to be down-regulated in lung cancer tissues compared with noncancerous counterparts. Finally, prognostic values of circPRKC1, circFGFR1, has-circ-00120123, circTP63, circ_0067934, CDR1as, hsa_circRN_103809 and some other circRNAs have been appraised in lung cancer. In the current manuscript, we describe the impact and utility of circRNAs in the pathology of lung cancer.