Manganese-Based Nanoscale Metal-Organic Frameworks for Magnetic Resonance Imaging
Manganese-Based Nanoscale Metal-Organic Frameworks for Magnetic Resonance Imaging
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DOI：
10.1021/ja803777x
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发表时间：
2008-11-05
影响因子：
15
通讯作者：
Lin, Wenbin
中科院分区：
文献类型：
--
作者：
Taylor, Kathryn M. L.;Rieter, William J.;Lin, Wenbin
采用反相微乳液法和表面活性剂辅助法分别在室温和120 ℃微波加热条件下合成了形貌可控的含锰纳米金属有机骨架（NMOFs）。使用多种方法对纳米颗粒进行表征，包括SEM、TEM、TGA、PXRD和ICP-MS。尽管纳米颗粒在每个Mn的基础上提供了适度的纵向弛豫率（r（1）），但它们提供了用于递送大剂量Mn 2+离子的有效载体，其在体外和体内表现出非常高的r（1）值，并提供了优异的MR对比度增强。颗粒表面也用二氧化硅壳改性，以允许环状RGD肽和有机荧光团的共价连接。Mn NMOFs上的细胞靶向分子增强了它们向癌细胞的递送，以允许体外靶向特异性MR成像。使用小鼠模型在体内也证明了MR对比增强。这种核-壳混合纳米结构提供了一个理想的平台，用于靶向递送其他成像和治疗剂到患病组织。
Manganese-containing nanoscale metal-organic frameworks (NMOFs) with controllable morphologies were synthesized using reverse-phase microemulsion techniques at room temperature and a surfactant-assisted procedure at 120 degrees C with microwave heating. The nanoparticles were characterized using a variety of methods including SEM, TEM, TGA, PXRD, and ICP-MS. Although the nanoparticles gave a modest longitudinal relaxivity (r(1)) on a per Mn basis, they provided an efficient vehicle for the delivery of large doses of Mn2+ ions which exhibited very high in vitro and in vivio r(1) values and afforded excellent MR contrast enhancement. The particle surface was also modified with a silica shell to allow covalent attachment of a cyclic RGD peptide and an organic fluorophore. The cell-targeting molecules on the Mn NMOFs enhanced their delivery to cancer cells to allow for target-specific MR imaging in vitro. The MR contrast enhancement was also demonstrated in vivo using a mouse model. Such core-shell hybrid nanostructures provide an ideal platform for targeted delivery of other imaging and therapeutic agents to diseased tissues.