Infections Requiring Hospitalization as Predictors of Pediatric-Onset Crohn's Disease and Ulcerative Colitis.
Infections Requiring Hospitalization as Predictors of Pediatric-Onset Crohn's Disease and Ulcerative Colitis.
复制标题
需要住院治疗的感染是小儿克罗恩病和溃疡性结肠炎的预测因素。
DOI：
10.1155/2015/690581
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发表时间：
2015
影响因子：
2
通讯作者：
Herrinton,LisaJ
中科院分区：
文献类型：
--
作者：
Hutfless,Susan;Abramson,Oren;Heyman,MelvinB;Bayless,TheodoreM;Li,De-Kun;Winthrop,Kevin;Herrinton,LisaJ
目的评估感染与儿童炎症性肠病（IBD）发病风险之间的关系。方法：我们对1996年至2006年间至少连续一年在北加州凯撒医疗机构就诊的501例年龄≤17岁的病例和9442例对照患者进行了巢式病例对照研究。小儿胃肠病学家确认了IBD并确定了发病日期。根据电子住院病历的主诊断代码识别住院感染。在住院期间确定了治疗感染的药物。使用条件logistic回归来评估住院感染、药物与克罗恩病和溃疡性结肠炎之间的关系。结果在诊断前一年，住院任一系统感染（OR 6.3; 95% CI 1.6-23.9）和住院肠道感染（OR 19.4; 95% CI 2.6-143.2）与CD相关。排除诊断前一年后，住院任一系统感染与UC呈负相关（OR 0.4; 95% CI 0.2-0.9）。没有UC病例在诊断前有住院胃肠道感染。结论在CD和UC诊断前，感染的作用似乎相反。感染可能与CD风险增加和UC风险降低有关。
ObjectivesTo assess the relationship between infections and the risk of pediatric‐onset inflammatory bowel disease (IBD).MethodsWe conducted a nested case‐control study of 501 incident cases aged ≤17 years and 9,442 controls who were members of Kaiser Permanente Northern California for at least one consecutive year between 1996 and 2006. IBD was confirmed and the incidence date was adjudicated by pediatric gastroenterologists. Hospitalized infections were identified from the principal diagnosis code of electronic inpatient records. Medications to treat infections were identified during the hospitalization. Conditional logistic regression was used to assess the associations between hospitalized infections, medications, and Crohn’s disease and ulcerative colitis.ResultsIn the year prior to diagnosis, both hospitalized infection of any system (OR 6.3; 95% CI 1.6–23.9) and hospitalized intestinal infection (OR 19.4; 95% CI 2.6–143.2) were associated with CD. Hospitalized infections of any system were inversely associated with UC after excluding the year prior to diagnosis (OR 0.4; 95% CI 0.2–0.9). No UC case had a hospitalized gastrointestinal infection prior to diagnosis.ConclusionInfections appear to play opposite roles prior to the diagnosis of CD and UC. Infections may be associated with an increased risk of CD and a decreased risk of UC.