Neural correlates of voluntary breathing in humans
Neural correlates of voluntary breathing in humans
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DOI：
10.1152/japplphysiol.00641.2002
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发表时间：
2003-09-01
影响因子：
3.3
通讯作者：
Corfield, DR
中科院分区：
文献类型：
--
作者：
McKay, LC;Evans, KC;Corfield, DR
为了研究自主呼吸控制的功能神经解剖学，对6名健康右利手个体在自主呼吸过度期间进行了血O（2）水平依赖性功能磁共振成像。在30秒自主呼吸周期与30秒等二氧化碳呼吸过度周期交替期间采集全脑功能图像[自主与自愿：潮气量= 0.5 +/- 0.01 vs. 1.3 +/- 0.1（SE）升，呼吸持续时间= 4.0 +/- 0.4 vs. 3.2 +/- 0.4（SE）s]。对于该组，自主呼吸过度与双侧初级感觉和运动皮质、辅助运动区、小脑、丘脑、尾状核和苍白球的显著（P < 0.05，经多重比较校正）神经活动相关。在上级背侧位置，还发现髓质（根据先验感兴趣区域的小体积校正进行多重比较校正）的活动显著增加（P = 0.012）。延髓内的活动表明脑干呼吸中枢可能在调节人类自主呼吸控制中起作用。
To investigate the functional neuroanatomy of voluntary respiratory control, blood O(2) level-dependent functional magnetic resonance imaging was performed in six healthy right-handed individuals during voluntary hyperpnea. Functional images of the whole brain were acquired during 30-s periods of spontaneous breathing alternated with 30-s periods of isocapnic hyperpnea [ spontaneous vs. voluntary: tidal volume = 0.5 +/- 0.01 vs. 1.3 +/- 0.1 (SE) liters and breath duration = 4.0 +/- 0.4 vs. 3.2 +/- 0.4 (SE) s]. For the group, voluntary hyperpnea was associated with significant ( P < 0.05, corrected for multiple comparisons) neural activity bilaterally in the primary sensory and motor cortices, supplementary motor area, cerebellum, thalamus, caudate nucleus, and globus pallidum. Significant increases in activity were also identified in the medulla ( corrected for multiple comparisons on the basis of a small volume correction for a priori region of interest) in a superior dorsal position ( P = 0.012). Activity within the medulla suggests that the brain stem respiratory centers may have a role in mediating the voluntary control of breathing in humans.