Fox transcription factors: from development to disease
Fox transcription factors: from development to disease
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DOI：
10.1242/dev.112672
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发表时间：
2016-12-15
期刊：
影响因子：
4.6
通讯作者：
Kaestner, Klaus H.
中科院分区：
文献类型：
--
作者：
Golson, Maria L.;Kaestner, Klaus H.
叉头盒（Fox）转录因子在从酵母到人类的生物体中是进化上保守的。它们调节发育期间和整个成年生活中的各种生物过程。许多Fox基因中的突变与人类疾病相关，因此，已经产生了各种动物模型来详细研究这些转录因子的功能。在许多情况下，即使缺少单个Fox转录因子也是致命的。在这篇文章中，我们提供了Fox家族的概述，突出了几个对哺乳动物发育很重要的关键Fox转录因子家族。
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human disease and, as such, various animal models have been generated to study the function of these transcription factors in mechanistic detail. In many cases, the absence of even a single Fox transcription factor is lethal. In this Primer, we provide an overview of the Fox family, highlighting several key Fox transcription factor families that are important for mammalian development.