BROAD SPECTRUM OF CYTOKINE ABNORMALITIES IN PANIC DISORDER AND POSTTRAUMATIC STRESS DISORDER
BROAD SPECTRUM OF CYTOKINE ABNORMALITIES IN PANIC DISORDER AND POSTTRAUMATIC STRESS DISORDER
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DOI：
10.1002/da.20564
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发表时间：
2009-05-01
影响因子：
7.4
通讯作者：
Simon, N. M.
中科院分区：
文献类型：
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作者：
Hoge, E. A.;Brandstetter, K.;Simon, N. M.
背景资料：据报道，在经历慢性压力的个体以及患有重度抑郁症的个体中，促炎细胞因子升高。对焦虑症如创伤后应激障碍（PTSD）和惊恐障碍（PD）中的细胞因子知之甚少。我们假设PD和PTSD与全身性促炎细胞因子信号相关。方法：我们利用Luminex技术检测了48名具有主要DSM-IV PD或PTSD诊断的良好特征的个体和48名年龄和性别匹配的健康对照的血清中的20种细胞因子和趋化因子。我们保守地采用Bonferroni校正进行多重检验（α = 0.05/20 = 0.0025）。结果如下：与年龄和性别匹配的健康对照组相比，原发性PTSD或PD患者的20种不同细胞因子中有18种的中位外周细胞因子水平显著升高（均P
Background: Proinflammatory cytokines have been reported to be elevated in individuals experiencing chronic stress as well as in those with major depressive disorde. Much less is known about cytokines in anxiety disorders such as Posttraumatic stress disorder (PTSD) and Panic disorder (PD). We hypothesized that PD and PTSD would be associated with a generalized proinflammatory cytokine signature. Method: We utilized Luminex technology to examine 20 cytokines and chemokines in serum from 48 well-characterized individuals with a primary DSM-IV PD or PTSD diagnosis, and 48 age- and gender-matched healthy controls. We conservatively employed a Bonferroni correction for multiple testing (alpha=.05/20 =.0025). Results: Individuals with primary PTSD or PD had significantly elevated median peripheral cytokine levels for 18 of 20 different cytokines compared to age- and gender-matched healthy controls (all P