Multi-physics modeling and finite element formulation of corneal UV cross-linking
Multi-physics modeling and finite element formulation of corneal UV cross-linking
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DOI：
10.1007/s10237-021-01463-3
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发表时间：
2021-05
影响因子：
3.5
通讯作者：
Shuolun Wang;Shawn A. Chester
中科院分区：
文献类型：
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作者：
Shuolun Wang;Shawn A. Chester
应用于角膜的UV交联技术是一种流行且有效的治疗眼部疾病如圆锥角膜和扩张性疾病的方法。这种治疗通过光化学反应形成新的交联来加强角膜，从而防止疾病进一步发展。为了更好地理解和捕捉潜在的机制，我们开发了一个多物理模型，该模型考虑了核黄素的迁移（即，光引发剂）、UV光吸收、形成交联的光化学反应以及由微结构变化引起的生物力学变化。我们的模型是校准到一组纳米压痕测试UV交联角膜从文献。此外，我们将我们的多物理场模型数值实现到商业有限元软件中。我们还比较了我们的模拟对一组通货膨胀测试从文献中。模拟功能使我们能够根据实际角膜几何形状对全3D治疗结果进行定量预测;它还可以帮助医生制定手术计划。
The UV cross-linking technique applied to the cornea is a popular and effective therapy for eye diseases such as keratoconus and ectatic disorders. The treatment strengthens the cornea by forming new cross-links via photochemical reactions and, in turn, prevents the disease from further developing. To better understand and capture the underlying mechanisms, we develop a multi-physics model that considers the migration of the riboflavin (i.e., the photo-initializer), UV light absorption, the photochemical reaction that forms the cross-links, and biomechanical changes caused by changes to the microstructure. Our model is calibrated to a set of nanoindentation tests on UV cross-linked corneas from the literature. Additionally, we implement our multi-physics model numerically into a commercial finite element software. We also compare our simulation against a set of inflation tests from the literature. The simulation capability allows us to make quantitative predictions of a therapy’s outcomes in full 3-D, based on the actual corneal geometry; it also helps medical practitioners with surgical planning.