Assessment of active tuberculosis findings in the eastern area of China: A 3-year sequential screening study
Assessment of active tuberculosis findings in the eastern area of China: A 3-year sequential screening study
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DOI：
10.1016/j.ijid.2019.07.029
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发表时间：
2019-11-01
影响因子：
8.4
通讯作者：
Jiang, Jianmin
中科院分区：
文献类型：
--
作者：
Liu, Kui;Peng, Ying;Jiang, Jianmin
背景资料：结核病是一个严重的全球性公共威胁，目前开展的结核病主动筛查效果的流行病学研究有限。方法：2013年在中国东部地区选择3个结核病筛查点，对15岁以上常住居民进行3轮系统筛查。经过多轮主动筛查，三个地点的结核病发病率均呈下降趋势，其中A地点的总体人群发病率变化显著。在A和B站点的目标人群中，通过第一轮或第二轮筛查，老年人和有结核病史的人都有显著下降。实施主动病例发现认定2.36 [1.47，3.81]（2013年与2012年）和1.49 [1.1，2.03]（2013-2015年对比2010-2012年）潜在病例多于A中心监测系统的被动病例发现。在结核病高发区、经济水平低的地区，特别是老年人和有结核病史的人群中，积极发现结核病病例可能是有效的。此外，应考虑采用新的快速诊断技术，以降低有结核病史者的患病率。最终，主动筛查比被动病例发现发现更多的主动结核病例，特别是在经济不发达的高患病率地区。(C)2019作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
Background: Tuberculosis (TB) is a critical global public threat, and limited epidemiology studies have been performed to explore the efficacy of active TB screening.Methods: Three sites located in eastern China were chosen in 2013, and three rounds of systematic screenings were performed in permanent residents aged older than 15 years.Results: The TB incidence showed a downtrend after several rounds of active screening at the three sites, and a significant change was observed at site A in the overall population. In the target population at sites A and B, both the elderly and people with a history of TB had a remarkable decline through the first or second round of screening. The implementation of active case-finding identified 2.36 [1.47,3.81] (2013 vs. 2012) and 1.49 [1.1,2.03] (2013-2015 vs. 2010-2012) more potential cases than the passive case-finding by the surveillance system at site A.Conclusions: Active case-finding of tuberculosis might be effective in high prevalence area with a low economic level, particularly among the elderly and people with a history of TB. Additionally, new rapid diagnosis technology should be considered to decrease the prevalence among people with a history of TB. Ultimately, active screening identified more active TB cases than passive case-finding, particularly in high prevalence area with underdeveloped economics. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.