Evaluation of anatomy-based dwell position and inverse optimization in high-dose-rate brachytherapy of prostate cancer: a dosimetric comparison to a conventional cylindrical dwell position, geometric optimization, and dose-point optimization
Evaluation of anatomy-based dwell position and inverse optimization in high-dose-rate brachytherapy of prostate cancer: a dosimetric comparison to a conventional cylindrical dwell position, geometric optimization, and dose-point optimization
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DOI：
10.1016/j.radonc.2005.02.006
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发表时间：
2005-06-01
影响因子：
5.7
通讯作者：
Murayama, S
中科院分区：
文献类型：
--
作者：
Yoshioka, Y;Nishimura, T;Murayama, S
背景和目的：比较前列腺癌高剂量率（HDR）近距离放射治疗的治疗计划方法。特别是，在确定驻留位置和驻留时间方面，定量评估基于解剖结构的驻留位置（ABDP）和逆优化（IO）相对于传统圆柱形驻留位置（CDP）、几何优化（GO）和剂量点优化（DO）的剂量学优效性（如果有的话）。2002年9月至2003年4月间，10例前列腺癌患者接受体外放射治疗时拍摄了治疗计划CT图像。使用治疗计划计算机软件和CT数据创建假设的HDR近距离放射治疗施源器针，将其正确植入前列腺中。每种情况下制定了6种不同的计划，包括IO with ABDP（IOABDP）、IO with CDP（IOCDP）、GO with ABDP（GO（ABDP））、GO with CDP（GO（CDP））、DO with ABDP（DOABDP）和DO with CDP（DOCDP），即总共60个计划。对所有计划进行标准化，使D-95等于处方剂量的100%。分析了所有60个计划的剂量-体积直方图，提取并比较了每个计划的多个植入物质量指标，包括Cl、El、DNR、%V-R75、%V-B75和%V-U150。结果：ABDP的E1显著低于IOABDP（P
Background and purpose: To compare treatment planning methods in high-dose-rate (HDR) brachytherapy of prostate cancer. In particular, to assess quantitatively the dosimetric superiority, if any, of the anatomy-based dwell position (ABDP) and inverse optimization (IO) over the conventional cylindrical dwell position (CDP), geometric optimization (GO), and dose-point optimization (DO) in terms of the determination of dwell positions and dwell times.Patients and methods: Between September 2002 and April 2003, 10 cases of treatment-planning CT images were taken for external radiotherapy for prostate cancer. Treatment planning computer software and the CT data were used to create hypothetical HDR brachytherapy applicator needles, which were properly implanted in the prostate. Six different plans including IO with ABDP (IOABDP), IO with CDP (IOCDP), GO with ABDP (GO(ABDP)), GO with CDP (GO(CDP)), DO with ABDP (DOABDP), and DO with CDP (DOCDP) were made for each case, that is, 60 plans in total. All plans were normalized so that the D-95 should be equal to 100% of the prescribed dose. Dose-volume histograms from all 60 plans were analyzed, and multiple implant quality indices, including Cl, El, DNR, %V-R75, %V-B75, and %V-U150 for each plan, were extracted and compared. Then, the best settings for IOABDP regarding dwell position and dose limit were sought for.Results: ABDP showed a statistically significantly lower El (P