Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study.
Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study.
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DOI：
10.1186/s12879-016-1989-x
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发表时间：
2016-11-08
影响因子：
3.7
通讯作者：
van Rie A
中科院分区：
文献类型：
--
作者：
Ncayiyana JR;Bassett J;West N;Westreich D;Musenge E;Emch M;Pettifor A;Hanrahan CF;Schwartz SR;Sanne I;van Rie A
南非是潜在结核病感染负担最高的高危人群之一，如幼儿、青少年、结核病家庭接触者、艾滋病毒携带者、金矿工人和卫生保健工作者，但人们对潜在结核病感染在其普通人群中的负担知之甚少。采用基于社区的随机抽样调查方法，对约翰内斯堡一个城镇的城市道路交通事故负担进行了调查，并调查了与城市道路交通事故相关的因素。LTB I的结果基于TST阳性，如果艾滋病毒携带者的硬结为≥5 mm或未知或阴性状态的人≥10 mm，则TST被视为阳性。采用双因素和多因素Logistic回归分析发现，LTBI的总患病率为34.3%(95%CI为30.0，38.8%)，0~14岁儿童年感染风险为3.1%(95%CI为2.1，5.2)。LTBI与HIV状态无关。多因素Logistic回归分析显示，LTBI与年龄(OR = 为1.03，95%CI = 1.01~1.05)、男性(OR = 2.70，95%CI = 1.55~4.70)、婚姻状况(OR = 2.00，95%CI = 1.31~3.54)、较高的社会经济状况(OR = 2.11，95%CI = 1.04~4.31)有关。在城市人群中，特别是在男性中，LTBI的患病率和感染结核分枝杆菌的年度风险很高，但与艾滋病毒感染状况无关。这项研究表明，LTBI可能与较高的SES相关，而不是结核病与贫困之间业已确立的联系。
South Africa has one of the highest burdens of latent tuberculosis infection (LTBI) in high-risk populations such as young children, adolescents, household contacts of TB cases, people living with HIV, gold miners and health care workers, but little is known about the burden of LTBI in its general population. Using a community-based survey with random sampling, we examined the burden of LTBI in an urban township of Johannesburg and investigated factors associated with LTBI. The outcome of LTBI was based on TST positivity, with a TST considered positive if the induration was ≥5 mm in people living with HIV or ≥10 mm in those with unknown or HIV negative status. We used bivariate and multivariable logistic regression to identify factors associated with LTBI The overall prevalence of LTBI was 34.3 (95 % CI 30.0, 38.8 %), the annual risk of infection among children age 0–14 years was 3.1 % (95 % CI 2.1, 5.2). LTBI was not associated with HIV status. In multivariable logistic regression analysis, LTBI was associated with age (OR = 1.03 for every year increase in age, 95 % CI = 1.01–1.05), male gender (OR = 2.70, 95 % CI = 1.55–4.70), marital status (OR = 2.00, 95 % CI = 1.31–3.54), and higher socio-economic status (OR = 2.11, 95 % CI = 1.04–4.31). The prevalence of LTBI and the annual risk of infection with M. tuberculosis is high in urban populations, especially in men, but independent of HIV infection status. This study suggests that LTBI may be associated with higher SES, in contrast to the well-established association between TB disease and poverty.
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影响因子：
5
作者：
Dodd PJ;Looker C;Plumb ID;Bond V;Schaap A;Shanaube K;Muyoyeta M;Vynnycky E;Godfrey-Faussett P;Corbett EL;Beyers N;Ayles H;White RG
通讯作者：
White RG
影响因子：
8
作者：
den Boon, Saskia;Verver, Suzanne;Beyers, Nulda
通讯作者：
Beyers, Nulda
影响因子：
3.7
作者：
KISH, L
通讯作者：
KISH, L
影响因子：
120.7
作者：
Dye, C;Scheele, S;Raviglione, RC
通讯作者：
Raviglione, RC
影响因子：
3.7
作者：
Kizza, Florence N.;List, Justin;Sekandi, Juliet N.
通讯作者：
Sekandi, Juliet N.