Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.
Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.
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DOI：
10.1088/1478-3975/8/3/035007
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发表时间：
2011-06
期刊：
影响因子：
2
通讯作者：
Panchenko AR
中科院分区：
文献类型：
--
作者：
Hashimoto K;Nishi H;Bryant S;Panchenko AR
许多可溶性蛋白和膜蛋白在细胞内形成同源低聚复合体，它们决定了许多途径的多样性和特异性，可能介导和调节基因表达、酶活性、离子通道、受体和细胞黏附过程。齐聚的进化和物理机制非常不同，其一般原理尚未形成。同源低聚状态在某些蛋白质亚家族中可能是保守的，在为某些底物提供特异性的同时最大限度地减少与其他不想要的伙伴的相互作用可能是重要的。此外，最近的研究使人们更加意识到，不同寡聚体状态之间的转换可能会调节蛋白质的活性，并提供不同途径之间的切换。在这篇综述中，我们综述了同源低聚体组装的生物学重要性，它们界面的物理化学性质，它们的识别和预测的实验和计算方法。我们特别关注同源低聚物的进化，并描述了通过形成不同的同源低聚复合体来发展新的特异性的机制。最后，我们讨论了寡聚体转变在蛋白质活性调控中的可能作用，并编写了一组具有这种调控机制的实验例子。
Many soluble and membrane proteins form homooligomeric complexes in a cell which are responsible for the diversity and specificity of many pathways, may mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and cell adhesion processes. The evolutionary and physical mechanisms of oligomerization are very diverse and its general principles have not yet been formulated. Homooligomeric states may be conserved within certain protein subfamilies and might be important in providing specificity to certain substrates while minimizing interactions with other unwanted partners. Moreover, recent studies have led to a greater awareness that transitions between different oligomeric states may regulate protein activity and provide the switch between different pathways. In this review we summarize the biological importance of homooligomeric assemblies, physico-chemical properties of their interfaces, experimental and computational methods for their identification and prediction. We particularly focus on homooligomer evolution and describe the mechanisms to develop new specificities through the formation of different homooligomeric complexes. Finally, we discuss the possible role of oligomeric transitions in the regulation of protein activity and compile a set of experimental examples with such regulatory mechanisms.
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