Hyperbaric oxygen therapy and liver transplantation.
Hyperbaric oxygen therapy and liver transplantation.
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DOI：
10.1080/13651820601175926
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Christophi, Chris
中科院分区：
文献类型：
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作者：
Muralidharan, Vijayaragavan;Christophi, Chris
肝移植是终末期肝病的首选治疗方法，常用于原发性肝脏恶性肿瘤。其更广泛应用的主要限制是缺乏合适的捐献器官。边缘供体器官的使用、分裂肝移植和活体相关肝移植技术的使用有助于增加供者池。然而，这些技术的使用与移植后器官功能障碍的风险增加相关，主要是由于缺血、保存和再灌注损伤(IPRI)。许多研究表明，高压氧(HBO)治疗会影响IPRI和由此导致的急性细胞排斥反应。本文回顾了高压氧治疗在移植领域的理论基础，特别强调了肝移植。
Liver transplantation is the treatment of choice for end stage liver disease and is often used for primary liver malignancies. The main limitation of its wider application is the availability of suitable donor organs. The use of marginal donor organs, split-liver transplantation and living-related liver transplantation techniques contribute to increase the donor pool. However, the use of these techniques is associated with a higher risk of post transplantation organ dysfunction, predominantly due to ischaemia, preservation and reperfusion injury (IPRI). A number of studies have demonstrated that hyperbaric oxygen (HBO) therapy influences IPRI and consequential acute cellular rejection. This article reviews the rationale of HBO therapy in the field of transplantation with particular emphasis on liver transplantation.