The human dorsal premotor cortex generates on-line error corrections during sensorimotor adaptation
The human dorsal premotor cortex generates on-line error corrections during sensorimotor adaptation
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DOI：
10.1523/jneurosci.3898-05.2006
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发表时间：
2006-03-22
影响因子：
5.3
通讯作者：
van Donkelaar, P
中科院分区：
文献类型：
--
作者：
Lee, JH;van Donkelaar, P
人类大脑中的许多不同区域已被证明在感觉运动适应中起作用。然而，人们对这些结构在学习过程中所起的具体作用知之甚少。在本研究中，通过经颅磁刺激（TMS）干扰运动前皮质背侧区域的活动，同时让佩戴棱镜眼镜的受试者指向视觉目标，来检验该区域的作用。当在整个运动过程中都能看到手时，这种操作减缓了适应速度，并减少了在线轨迹修正的出现。同时，手臂的感知位置偏移也减少了。相比之下，当仅在运动结束时才能看到手时，TMS并未导致该任务的表现发生任何改变。因此，我们从这些结果模式推断，人类运动前皮质背侧区域有助于产生基于视觉的在线误差修正，这种修正负责感觉运动适应背后的手臂位置感的重新映射。
A number of different sites in the human brain have been shown to play a role in sensorimotor adaptation. However, the specific role played by each of these structures in the learning process is poorly understood. In the present study, the contribution of the dorsal aspect of the premotor cortex was examined by disrupting activity at this site using transcranial magnetic stimulation (TMS) while subjects wearing prism goggles pointed at visual targets. This manipulation slowed down the rate of adaptation when vision of the hand was available throughout the movement and reduced the presence of on-line trajectory corrections. This was accompanied by a reduced shift in the felt position of the arm. In contrast, TMS did not cause any alteration in the performance of this task when vision of the hand was available only at the end of the movement. Thus, we infer from this pattern of results that the human dorsal premotor cortex contributes to the generation of the visually based on-line error corrections that are responsible for the remapping of arm position sense underlying sensorimotor adaptation.