Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.
Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.
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脑源性神经营养因子表达的升高有利于雏鸡的视觉印记。
DOI：
10.1111/jnc.12039
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发表时间：
2012
影响因子：
4.7
通讯作者：
Keiko Suzuki
中科院分区：
文献类型：
--
作者：
浜崎 浩子;前川文彦;Tomoharu Nakamori;Fumihiko Maekawa;浜崎 浩子;Keiko Suzuki
为了阐明早期学习的神经机制，我们研究了脑源性神经营养因子（BDNF）在鸟类视觉印迹中的作用。连接视觉皮层和中间中皮层的远端脑神经回路对印记至关重要，而位于该回路中心的高白质致密细胞（HDCo）的核心区域在调节该回路的活动中起着关键作用。我们发现HDCo中bdnfmrna阳性细胞的数量在关键时期升高，特别是在孵化当天（P0）。在P1上进行印迹训练后，HDCo中BDNFmRNA阳性细胞数量增加，TrkB酪氨酸磷酸化。在P1时将BDNF注入HDCo诱导印迹，即使采用通常不会诱导印迹的弱训练方案。相反，Trk拮抗剂K252a抑制印迹。关键时期过后，在P7部位注射BDNF没有引起印迹。这些结果表明，在关键时期，BDNF仅通过TrkB促进印迹的诱导。
With the aim of elucidating the neural mechanisms of early learning, we studied the role of brain‐derived neurotrophic factor (BDNF) in visual imprinting in birds. The telencephalic neural circuit connecting the visual Wulst and intermediate medial mesopallium is critical for imprinting, and the core region of the hyperpallium densocellulare (HDCo), situated at the center of this circuit, has a key role in regulating the activity of the circuit. We found that the number ofBDNFmRNA‐positive cells in the HDCo was elevated during the critical period, particularly at its onset, on the day of hatching (P0). After imprinting training on P1,BDNFmRNA‐positive cells in the HDCo increased in number, and tyrosine phosphorylation of TrkB was observed. BDNF infusion into the HDCo at P1 induced imprinting, even with a weak training protocol that does not normally induce imprinting. In contrast, K252a, an antagonist of Trk, inhibited imprinting. Injection of BDNF at P7, after the critical period, did not elicit imprinting. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period.