Blood pressure dipping and sleep disturbance in African-American and Caucasian men and women
Blood pressure dipping and sleep disturbance in African-American and Caucasian men and women
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DOI：
10.1038/ajh.2008.183
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发表时间：
2008-07-01
影响因子：
3.2
通讯作者：
Reis, Steven E.
中科院分区：
文献类型：
--
作者：
Matthews, Karen A.;Kamarck, Thomas W.;Reis, Steven E.
夜间/日间血压（BP）比值升高与心血管疾病发病率和死亡率相关。我们评估了睡眠/清醒血压比与睡眠障碍之间的相关性。方法通过9晚的家庭腕动计和日记测量以及2晚的多导睡眠图（PSG）评估睡眠障碍;测量动态血压至少48小时。参与者是186名中年非洲裔美国人和白人男性和女性，他们没有普遍的心肌梗死、中风、介入心脏病学手术史、糖尿病和诊断的呼吸暂停或其他睡眠障碍。第1阶段（轻度）睡眠的比例越大，快速眼动（REM）睡眠的比例越小，从睡眠中醒来的次数越多。这些结果与年龄、种族、性别、心脏病风险状态、心血管药物、体重指数和呼吸暂停/低通气指数无关。社会心理压力的指标并没有更大的那些较高的睡眠/清醒BP ratios. CONCLUSION结果是一致的假设，夜间/白天的压力升高可能是睡眠不佳的后果。
BACKGROUNDElevated night time/daytime blood pressure (BP) ratios are associated with cardiovascular morbidity and mortality. We evaluated the associations between sleep/awake BP ratios and sleep disturbances.METHODSSleep disturbances were assessed by in-home actigraphy and diary measures for nine nights, and polysomnography (PSG) for two nights; ambulatory BP was measured for at least 48 h. Participants were 186 middle-aged African-American and Caucasian men and women who were free from prevalent myocardial infarction, stroke, history of interventional cardiology procedures, diabetes, and diagnosed apnea or other sleep disorders.RESULTSResults showed that the greater the sleep/wake ratios of BP, the more fragmented the sleep, the greater the proportion in stage 1 (light) sleep and the smaller the proportion in rapid eye movement (REM) sleep, and the greater the number of arousals from sleep. These results were independent of age, race, gender, Framingham Risk status, cardiovascular medications, body mass index, and apnea/hypopnea index. Indicators of psychosocial stress were not greater among those with higher sleep/wake BP ratios.CONCLUSIONSFindings are consistent with the hypothesis that elevated night time/daytime pressure may be a consequence of poor sleep.