Effect of Repetitive Transcranial Magnetic Stimulation on Cognition and Mood in Stroke Patients A Double-Blind, Sham-Controlled Trial
Effect of Repetitive Transcranial Magnetic Stimulation on Cognition and Mood in Stroke Patients A Double-Blind, Sham-Controlled Trial
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DOI：
10.1097/phm.0b013e3181d8a5b1
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发表时间：
2010-05-01
影响因子：
3
通讯作者：
Kwon, Jae Sung
中科院分区：
文献类型：
--
作者：
Kim, Bo Ryun;Kim, Dae-Yul;Kwon, Jae Sung
目的：探讨重复经颅磁刺激对卒中后患者认知功能和情绪的影响。设计：单中心、前瞻性、双盲、假对照初步研究。18例患者(男10例，女8例；平均年龄62.9岁)入选。所有参与者被随机分配到三个处理组之一：低频(1赫兹)刺激、高频(10赫兹)刺激和假刺激(对照组)。每名患者接受10次连续治疗(每周5次，共2周)。认知功能评定采用计算机神经心理学测验，执行功能评定采用伦敦塔测验，日常生活活动能力评定采用改良Barthel指数评分，情绪状态评定采用Beck抑郁量表。结果：治疗对三组患者的认知功能参数，包括伦敦塔评分均无显著影响。相比之下，高频重复经颅磁刺激导致Beck抑郁问卷评分显著低于基线，并与其他两组相比。修改后的Barthel指数得分在三组中均显著增加。结论：这些初步数据表明，这对情绪有积极的影响，但这项研究并未发现对认知的任何可测量的影响。
Objective: This study examined whether repetitive transcranial magnetic stimulation applied over the left dorsolateral prefrontal cortex (DLPFC) affected cognition or mood in poststroke patients.Design: The study was a single-center, prospective, double-blind, sham-controlled preliminary study. Eighteen patients (10 males and 8 females; average age, 62.9 yrs) were enrolled. All participants were randomly assigned to one of three treatment groups: low-frequency (1 Hz) stimulation, high-frequency (10 Hz) stimulation, and sham stimulation (control). Each patient underwent 10 consecutive treatment sessions (five times per week for 2 wks). A Computerized Neuropsychological Test was used to evaluate cognitive function, the Tower of London test was used to assess executive function, the Modified Barthel Index score was used to assess activity of daily living function, and the Beck Depression Inventory was used to assess mood status. These evaluations were conducted in all patients before and after treatment.Results: Treatment had no significant effect on any cognitive function parameter, including the Tower of London scores, in any of the three groups. In contrast, high-frequency repetitive transcranial magnetic stimulation resulted in significantly lower Beck Depression Inventory scores compared with baseline and compared with the other two groups. The Modified Barthel Index scores significantly increased in all three groups.Conclusions: These preliminary data suggest that there was a positive effect on mood, but the study was not powered to detect any measurable effect on cognition.