Induction of scratching behaviour and dermatitis in various strains of mice cohabiting with NC/Nga mice with chronic dermatitis
Induction of scratching behaviour and dermatitis in various strains of mice cohabiting with NC/Nga mice with chronic dermatitis
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DOI：
10.1111/j.1365-2133.2005.06879.x
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发表时间：
2006-01-01
影响因子：
10.3
通讯作者：
Nakaike, S
中科院分区：
文献类型：
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作者：
Hashimoto, Y;Arai, I;Nakaike, S
背景NC/Nga（NC）小鼠具有与人类特应性皮炎中所见相似的病理和行为特征，被用作该疾病的模型。正常情况下，NC小鼠会出现自发的、持续的抓挠行为，这会导致皮肤炎症的发生。目的通过与患皮炎的NC小鼠、BALB/c小鼠、ICR小鼠和C3 H/HeN小鼠同居，观察其抓挠行为的诱导，以及NC小鼠和BALB/c小鼠的皮炎诱导。将ICR和C3 H/HeN小鼠与慢性皮炎的NC小鼠（CNV-NC）一起饲养2周，并计数抓挠发作次数。NC和BALB/c小鼠也与CNV-NC小鼠一起保持24周，并评估皮肤严重程度评分。结果与CNV-NC小鼠同居后，NC、BALB/c、ICR和C3 H/HeN小鼠的抓挠次数均增加。与CNV-NC小鼠同居导致NC和BALB/c小鼠的皮炎。BALB/c小鼠的抓挠次数和皮肤严重程度评分约为NC小鼠的一半。当与CNV-NC小鼠停止同居时，BALB/c小鼠的抓挠发作次数和皮肤严重程度评分降低，但NC小鼠没有。BALB/c小鼠的组织病理学数据的变化支持皮肤inflammation. Conclusions的严重程度，我们的研究表明，抓挠行为和皮炎可以诱导在不同品系的小鼠与CNV-NC小鼠同居，并停止同居导致恢复BALB/c小鼠，但不是在NC小鼠。
Background NC/Nga (NC) mice with similar pathological and behavioural features as seen in human atopic dermatitis are used as a model of the disease. Under normal circumstances, spontaneous and persistent scratching occurs in NC mice and this can lead to the onset of skin inflammation.Objectives We examined the induction of scratching behaviour in NC, BALB/c, ICR and C3H/HeN mice, and of dermatitis in NC and BALB/c mice, by cohabitation with mice with dermatitis.Methods NC, BALB/c, ICR and C3H/HeN mice were kept together with NC mice with chronic dermatitis (CNV-NC) for 2 weeks, and the numbers of scratching episodes were counted. NC and BALB/c mice were also kept together with CNV-NC mice for 24 weeks and the skin severity score was assessed. The score was assessed for a further 8 weeks after separation of these mice.Results The number of scratching episodes in NC, BALB/c, ICR and C3H/HeN mice was increased by cohabitation with CNV-NC mice. Cohabitation with CNV-NC mice led to dermatitis in both NC and BALB/c mice. The number of scratching episodes and the skin severity score in BALB/c mice were about half of those in NC mice. When cohabitation with CNV-NC mice stopped, the number of scratching episodes and the skin severity score decreased in BALB/c mice, but not in NC mice. Changes in the histopathological data of BALB/c mice supported the severity of skin inflammation.Conclusions Our study demonstrates that scratching behaviour and dermatitis can be induced in various strains of mice by cohabitation with CNV-NC mice, and that cessation of cohabitation leads to a recovery in BALB/c mice but not in NC mice.