The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B
The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B
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DOI：
10.1136/gutjnl-2015-310686
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发表时间：
2016-09-01
期刊：
影响因子：
24.5
通讯作者：
Chen, Chien-Jen
中科院分区：
文献类型：
--
作者：
Hu, Hui-Han;Liu, Jessica;Chen, Chien-Jen
目的新近发现由SLC10A1编码的牛磺胆酸钠共转运多肽（NTCP）是HBV的一种受体。我们评估了p.Ser267Phe变异（rs2296651）与慢性乙型肝炎（CHB）患者血清状态、肝硬化和肝细胞癌（HCC）的关系。设计对3801例CHB患者和3801例匹配的乙型肝炎表面抗原（HBsAg）血清阴性个体进行基因分型。使用logistic回归估计该变异与CHB、肝硬化和HCC相关的or值为95% CIs。结果在CHB患者中，515例（18.5%）对照、40例（17.2%）单纯肝硬化患者、49例（13.2%）非肝硬化HCC患者和52例（12.7%）肝硬化合并HCC患者中观察到S267F变异。在对已知危险因素进行校正后，S267F与肝硬化（OR 0.65 (95% CI 0.49 ~ 0.86), p=0.002）和HCC (OR 0.55 （95% CI 0.42 ~ 0.72）的风险降低显著相关
Objective The sodium taurocholate co-transporting polypeptide (NTCP), encoded by SLC10A1, was recently identified as a receptor for HBV. We assessed the association of the p.Ser267Phe variant (rs2296651) with chronic hepatitis B (CHB) serostatus, cirrhosis and hepatocellular carcinoma (HCC) in patients with CHB.Design The variant was genotyped in 3801 patients with CHB and 3801 matched hepatitis B surface antigen (HBsAg) seronegative individuals. ORs with 95% CIs for the variant's association with CHB, cirrhosis and HCC were estimated using logistic regression.Results In patients with CHB, the S267F variant was observed in 515 (18.5%) controls, 40 (17.2%) cirrhosis only cases, 49 (13.2%) non-cirrhotic HCC cases, and 52 (12.7%) cirrhotic-HCC cases. After adjustment for known risk factors, S267F was significantly associated with decreased risk for cirrhosis (OR 0.65 (95% CI 0.49 to 0.86), p=0.002) and HCC (OR 0.55 (95% CI 0.42 to 0.72), p