Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies
Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies
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DOI：
10.1002/anie.200504555
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
DiMagno, SG
中科院分区：
文献类型：
--
作者：
Sun, H;DiMagno, SG
(给出的化学方程式)驯化试剂：研究了无水四丁基氟化铵(TBAF ANH)在亲核芳香取代反应中的应用，包括选择性卤素交换和氟代硝化过程的变体(见方案)。结果表明，如果在相对非极性的介质中使用，TBAF和ANH允许在令人惊讶的温和条件下进行这些反应。
(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAF anh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAF anh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.