Selective recognition and separation of β-lactam antibiotics using molecularly imprinted polymers
Selective recognition and separation of β-lactam antibiotics using molecularly imprinted polymers
复制标题
利用分子印迹聚合物选择性识别和分离β-内酰胺类抗生素
DOI：
10.1039/a905151a
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
O. Ramström
中科院分区：
文献类型：
--
作者：
Kristina Skudar;O. Brüggemann;A. Wittelsberger;O. Ramström
制备了青霉素V和苯唑西林的分子印迹聚合物，并研究了其在有机相和水相中的识别性能。由此产生的分子印迹聚合物被证明是有效的区分不同的青霉素（青霉素V，青霉素G和苯唑西林），但也可以准备识别青霉素作为一个组。结果表明，分子印迹聚合物可用于制备青霉素类药物的选择性或通用性识别基质，在分离和检测方面具有潜在的应用价值。
Molecularly imprinted polymers (MIPs) to penicillin V or oxacillin were prepared, and their recognition properties were investigated, both in organic and aqueous phases. The resulting MIPs proved to be efficient in distinguishing between different penicillins (penicillin V, penicillin G and oxacillin), but could also be prepared to recognise the penicillins as a group. The results indicate that MIPs can be used to prepare either selective or general recognition matrices for penicillins, which can be of potential use in separation and detection applications.