Mechanisms of weight loss and improved metabolism following bariatric surgery.
Mechanisms of weight loss and improved metabolism following bariatric surgery.
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DOI：
10.1111/nyas.13409
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发表时间：
2018-01
影响因子：
5.2
通讯作者：
Patti ME
中科院分区：
文献类型：
--
作者：
Mulla CM;Middelbeek RJW;Patti ME
减肥手术越来越被认为是最有效的干预措施之一，可以帮助患者实现显着和持续的体重减轻，以及改善代谢和整体健康。不幸的是，减肥手术实现减肥的细胞和生理机制尚未完全阐明，但对于了解肠道在全身代谢中的核心作用和开发治疗肥胖的新策略至关重要。在这篇综述中，我们提供了一个概述的潜在机制，有助于减肥，包括调节能量平衡和中枢和外周神经系统调节食欲和代谢的影响。此外，我们强调了胃肠道的重要性，包括胆汁酸生理学的改变，分泌的激素和微生物组，作为一个有效的调解人，改善代谢后的肥胖患者。
Bariatric surgery is increasingly recognized as one of the most effective interventions to help patients achieve significant and sustained weight loss, as well as improved metabolic and overall health. Unfortunately, the cellular and physiological mechanisms by which bariatric surgery achieves weight loss have not been fully elucidated yet are critical to understand the central role of the intestinal tract in whole-body metabolism and to develop novel strategies for the treatment of obesity. In this review, we provide an overview of potential mechanisms contributing to weight loss, including effects on regulation of energy balance and both central and peripheral nervous system regulation of appetite and metabolism. Moreover, we highlight the importance of the gastrointestinal tract, including alterations in bile acid physiology, secretion of intestinally derived hormones, and the microbiome, as a potent mediator of improved metabolism in postbariatric patients.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
9
作者：
BROLIN, RE;ROBERTSON, LB;CODY, RP
通讯作者：
CODY, RP
影响因子：
8.2
作者：
Cummings DE;Arterburn DE;Westbrook EO;Kuzma JN;Stewart SD;Chan CP;Bock SN;Landers JT;Kratz M;Foster-Schubert KE;Flum DR
通讯作者：
Flum DR
影响因子：
16.9
作者：
Courcoulas, Anita P.;Goodpaster, Bret H.;Eagleton, Jessie K.;Belle, Steven H.;Kalarchian, Melissa A.;Lang, Wei;Toledo, Frederico G. S.;Jakicic, John M.
通讯作者：
Jakicic, John M.
影响因子：
3.1
作者：
Coleman, Karen J.;Huang, Yii-Chieh;Brookey, John
通讯作者：
Brookey, John