Attentional response at eight weeks in prenatally drug-exposed and preterm infants
Attentional response at eight weeks in prenatally drug-exposed and preterm infants
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DOI：
10.1016/s0892-0362(99)00023-9
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发表时间：
1999-09-01
影响因子：
2.9
通讯作者：
Lynch, ME
中科院分区：
文献类型：
--
作者：
Coles, CD;Bard, KA;Lynch, ME
为了评估产前多种药物暴露对婴儿注意力的影响，对105名8周大的非裔美国婴儿进行了一系列刺激，并记录了他们的心率（hr）。根据母亲的药物使用情况对婴儿进行产后鉴定。分为四组：1)药物暴露早产儿（n = 25）；2)足月，药物暴露（n = 32）；3)早产儿未暴露（n = 22）；4)足月未暴露（n = 26）。纠正了早产儿的年龄。记录婴儿的基线hr，然后按以下顺序呈现刺激：听觉（响动）、视觉（红环）和社交（考官的脸和声音）。在基线或听觉或视觉条件下没有HR差异。然而，对社会刺激的反应有显著差异（F(2,103) = 6.54, p < 0.01）。药物暴露的婴儿表现出加速的HR反应，表明焦虑或兴奋，而对照组婴儿表现出减速反应，表明注意力集中，由于早产婴儿的HR反应更大，因此存在相互作用。分层回归分析显示，可卡因（R-2 = 0.034, p < 0.05）是导致差异的因素，其他药物使用和父母不稳定（R-2 = 0.137, p < 0.001）与差异无关。(C) 1999 Elsevier Science Inc.；版权所有。
To evaluate the effect of prenatal polydrug exposure on infant attention, 105 8-week-old African-American infants were presented a series of stimuli and their heart rates (HRs) were recorded. Infants were identified postnatally based on mothers' substance use. Four groups were tested: 1) preterm drug-exposed infants (n = 25); 2) full-term, drug-exposed (n = 32); 3) preterm nonexposed (n = 22); and 4) full-term, nonexposed (n = 26). Preterm infants' ages were corrected. Infant's baseline HRs were recorded and then stimuli presented in the following order: auditory (rattle), visual (red ring), and social (examiner's face and voice). There were no HR differences at baseline or in auditory or visual conditions. However, significant differences (F(2, 103) = 6.54, p < 0.01) were seen in response to social stimuli. Drug-exposed infants showed an acceleratory HR indicating distress or arousal and control infants showed a deceleratory response indicating focused attention and there was an interaction due to greater HR response in preterms. Hierarchical regression indicated cocaine (R-2 = 0.034, p < 0.05) but not other drug use and instability in parenting (R-2 = 0.137, p < 0.001) accounted for the observed differences. (C) 1999 Elsevier Science Inc. All rights reserved.