STUDIES ON THE DEVELOPMENTAL TOXICITY OF OZONE .1. PRENATAL EFFECTS
STUDIES ON THE DEVELOPMENTAL TOXICITY OF OZONE .1. PRENATAL EFFECTS
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DOI：
10.1016/s0041-008x(79)80004-6
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发表时间：
1979-01-01
影响因子：
3.8
通讯作者：
GRABOWSKI, CT
中科院分区：
文献类型：
--
作者：
KAVLOCK, R;DASTON, G;GRABOWSKI, CT
臭氧是光化学烟雾中的主要氧化剂，可产生肺和全身毒性。Long-Evans大鼠在妊娠早期（第6-9天）、中期（第9-12天）或晚期（第17-20天）或整个器官形成期（第6-15天）暴露于浓度为0-1.97 ppm的臭氧中。没有畸胎产生的任何方案，但吸收率增加后，暴露于浓度高于1.26 ppm的臭氧在妊娠中期。暴露于环境水平（0.44 ppm）为8小时/天期间的器官形成没有产生显着的影响。在第20天检查时，妊娠中期或晚期暴露于1 ppm未改变胎仔心率、ECG、血细胞比容和血浆电解质。水杨酸钠（第10天150 mg/kg）与臭氧（妊娠中期1 ppm）具有协同作用，因为联合治疗降低了胎儿体重，并在较小程度上增加了吸收率。这些影响在单独给药的任一治疗中均极轻微。
Ozone, the predominant oxidant in photochemical smog, produces pulmonary and systemic toxicities. Long-Evans rats were exposed during early (Day 6-9), mid (Day 9-12) or late (Day 17-20) gestation or throughout the period of organogenesis (Day 6-15) to concentrations of ozone varying from 0-1.97 ppm. No terata were produced by any regimen, but the resorption rate was increased following exposure to concentrations of ozone above 1.26 ppm in midgestation. Exposure to ambient levels (0.44 ppm) for 8 h/day during the period of organogenesis produced no significant effects. Fetal heart rates, ECG, hematocrits and plasma electrolytes were unaltered by exposure to 1 ppm during mid- or late gestation when examined on Day 20. Sodium salicylate (150 mg/kg on Day 10) was synergistic with ozone (1 ppm in midgestation), in that the combined treatment decreased fetal wt and to a lesser extent increased the resorption rate. These effects were minimal from either treatment administered alone.