Arguments in favour of remdesivir for treating SARS-CoV-2 infections
Arguments in favour of remdesivir for treating SARS-CoV-2 infections
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DOI：
10.1016/j.ijantimicag.2020.105933
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发表时间：
2020-04-01
影响因子：
10.8
通讯作者：
Hsueh, Po-Ren
中科院分区：
文献类型：
--
作者：
Ko, Wen-Chien;Rolain, Jean-Marc;Hsueh, Po-Ren
已知SARS-CoV-2感染的疾病谱系，即所谓的2019冠状病毒病（COVID-19），其严重程度各不相同，从无症状携带到轻度呼吸道感染以及严重或致命的肺炎。此外，SARS-CoV-2可在家庭、社区、邮轮乘客和医院中传播，已成为世界卫生组织（世卫组织）于2020年1月30日宣布的国际关注的突发公共卫生事件（PHEIC）。截至2020年2月28日，56个国家和地区报告了COVID-19实验室确诊病例，全球报告病例超过83882例；其中超过78 832例报告来自中国（https://www）。worldometers。信息/冠状病毒)。在病毒学家看来，人类和人畜共患的冠状病毒都属于冠状病毒科，属于尼多病毒目。目前，冠状病毒科冠状病毒亚科有4个属：甲型冠状病毒、倍冠状病毒、德尔塔冠状病毒和伽玛冠状病毒。在本次COVID-19流行之前，有六种公认的人类呼吸道冠状病毒，包括HCoV-229E（甲型冠状病毒）、HCoV-OC43（乙型冠状病毒）、HCoV-NL63（甲型冠状病毒）和HKU1（乙型冠状病毒），它们通常引起轻度呼吸道感染，而SARS-CoV和MERS-CoV则可导致严重甚至致命的下呼吸道疾病[9]。第七种人类冠状病毒是SARS-CoV-2，属于冠状病毒属，该属还包括SARS-CoV和MERS-CoV。
Since the end of 2019, an increasing number of cases of pneumonia were reported in Wuhan, followed by other cities and provinces in China and many other countries [1],[2],[3],[4],[5],[6],[7], and the 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[8], a new human pathogen, was identified as the cause of Wuhan pneumonia. The disease spectrum of SARS-CoV-2 infection, so-called coronavirus disease 2019 (COVID-19), was known to be diverse in severity, ranging from asymptomatic carriage to mild respiratory tract infection and severe or fatal pneumonia. Moreover, SARS-CoV-2 can be transmitted within the family, in the community, among cruise passengers and in hospitals, and has become a public-health emergency of international concern (PHEIC), declared by the World Health Organization (WHO) on 30 January 2020. As of 28 February 2020, laboratory-confirmed cases of COVID-19 have been reported in 56 countries and territories with more than 83 382 cases reported globally; more than 78 832 of these cases were reported from China (https://www. worldometers. info/coronavirus/).In the view of virologists, human and zoonotic coronaviruses belong to the family Coronaviridae in the order Nidovirales. Currently, there are four genera in the subfamily Coronavirinae of the family Coronaviridae: Alphacoronavirus, Betacoronavirus, Deltacoronavirus and Gammacoronavirus. Before the current COVID-19 epidemic, there were six recognised human respiratory coronaviruses, including HCoV-229E (Alphacoronavirus), HCoV-OC43 (Betacoronavirus), HCoV-NL63 (Alphacoronavirus) and HKU1 (Betacoronavirus) that often cause mild respiratory tract infection as well as SARS-CoV and MERS-CoV that in contrast can lead to severe or even fatal lower respiratory tract disease [9]. The seventh human coronavirus, SARS-CoV-2, belongs to the genus Betacoronavirus, which also contains SARS-CoV and MERS-CoV.