The cell biology of receptor-mediated virus entry.

The cell biology of receptor-mediated virus entry.
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DOI:
10.1083/jcb.201108131
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发表时间:
2011-12-26
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Marsh M
Marsh M
中科院分区:
其他
文献类型:
--
作者:
Grove J;Marsh M

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细胞对病毒进入施加了多重屏障。然而,病毒利用基本的细胞过程进入细胞并运送其遗传货物。病毒进入途径主要由病毒颗粒与其细胞表面受体之间的相互作用来定义。这些相互作用决定了病毒附着、摄取、细胞内运输以及最终渗透到胞质溶胶的机制。阐明病毒及其受体之间复杂的相互作用对于全面了解这些非凡的代理人如何入侵其细胞宿主是必要的。
The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways are largely defined by the interactions between virus particles and their receptors at the cell surface. These interactions determine the mechanisms of virus attachment, uptake, intracellular trafficking, and, ultimately, penetration to the cytosol. Elucidating the complex interplay between viruses and their receptors is necessary for a full understanding of how these remarkable agents invade their cellular hosts.
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