Tubulointerstitial actions of endothelins in the kidney: roles in health and disease
Tubulointerstitial actions of endothelins in the kidney: roles in health and disease
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内皮素在肾脏中的肾小管间质作用：在健康和疾病中的作用
DOI：
10.1093/oxfordjournals.ndt.a027249
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发表时间：
1996
影响因子：
6.1
通讯作者：
A. Ong
中科院分区：
文献类型：
--
作者：
A. Ong
自 1988 年发现 ET-1 以来 [1]，很少有分子像内皮素肽家族（ET-1、ET-2、ET-3）及其受体（ETA、ETB、ETC）一样受到如此严格的审查。然而，许多研究充其量只是对它们在健康和疾病中的调节和作用的了解有限。也许“内皮素疲劳”开始陷入困境并不奇怪，即使是在最忠诚的研究人员中也是如此！然而，在过去的一年里，一些新的重大进展使人们对这些肽重新产生了兴趣。首先，内皮素及其受体已被证明对于小鼠胎儿神经嵴衍生组织的发育至关重要。此外，它们还与至少两种特定的人类疾病有关[2-6]。其次，内皮素转化酶（ECE-1）是调节内皮素合成和作用的重要治疗靶点，已被克隆[7]。第三，选择性、有效且具有口服活性的内皮素受体拮抗剂现已上市[8-10]。最后，肾缺血后 24 小时给予内皮素受体拮抗剂，已被证明可以通过特异性刺激肾小管恢复来逆转大鼠的严重急性肾小管坏死[11]。因此，尽管内皮素研究的主要焦点是血管张力的调节（由于其发现的性质），但现在显然内皮素的一些基本功能实际上是关于非血管组织的生长和发育。有关内皮素在肾脏中的作用的更全面的说明，感兴趣的读者可以参考。到最近的几个帐户 [12, 13]。我的目的不是为这些文献添加内容。相反，由于内皮素肾脏研究的主要焦点不可避免地集中在肾小球功能和血管张力的控制上，我的目的是证明肾小管间质实际上是肾脏中 ET-1 合成和作用的主要部位。然而，实验数据的解释由于重要物种而变得复杂
Since the discovery of ET-1 in 1988 [1], few molecules have come under such intense scrutiny as the endothelin peptide family (ET-1, ET-2, ET-3) and their receptors (ETA, ETB, ETC). Much study had nevertheless given rise to, at best, a limited understanding of their regulation and roles in health and disease. Perhaps it was not surprising that'endothelin fatigue'had begun to sink in, even among the most committed researchers!In the past year, however, several new and significant developments have led to a renewed interest in these peptides. Firstly endothelins and their receptors have been shown to be essential for the development of fetal neural crest derived tissues in mice. In addition, they have been implicated in at least two specific human diseases [2-6]. Secondly the endothelin converting enzyme (ECE-1), an important therapeutic target for modulating endothelin synthesis and action, has been cloned [7]. Thirdly selective, potent and orally active endothelin receptor antagonists are now available [8-10]. Finally an endothelin receptor antagonist given 24 h after renal ischaemia, has been shown to reverse severe acute tubular necrosis in rats, by specifically stimulating tubular recovery [11]. Thus, although the major focus in endothelin research has been on the regulation of vascular tone (because of the nature of their discovery), it is now apparent that some of the essential functions of the endothelins are actually on growth and development in non-vascular tissues. For a more comprehensive account of the roles of endothelins in the kidney, the interested reader may refer. to several recent accounts [12, 13]. It is not my purpose to add to this literature. Rather, since the major focus of endothelin renal research has inevitably concentrated on the control of glomerular function and vascular tone, my aim is to show that the tubulointerstitium is in fact, the major site of ET-1 synthesis and action in the kidney. Interpretation of experimental data is nevertheless complicated by important species
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前列腺素 E2 消除内皮素诱导的大鼠肾外髓质降血管直肠血管收缩。
DOI：
10.1172/jci117976
发表时间：
1995
期刊：
The Journal of clinical investigation.
影响因子：
--
作者：
Silldorff,EP;Yang,S;Pallone,TL
通讯作者：
Pallone,TL
DOI：
10.1172/jci118050
发表时间：
1995-07
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
A. K. Hughes;W. Barry;D. Kohan
通讯作者：
A. K. Hughes;W. Barry;D. Kohan
直肠升血管壁对白蛋白进行分子筛分。
DOI：
10.1172/jci115852
发表时间：
1992
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Pallone,TL
通讯作者：
Pallone,TL
内皮素，完整肾小管上皮细胞中 Na( )-K( )-ATP 酶的肽抑制剂。
DOI：
10.1152/ajpcell.1989.257.6.c1101
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Zeidel,ML;Brady,HR;Kone,BC;Gullans,SR;Brenner,BM
通讯作者：
Brenner,BM
影响因子：
--
作者：
BRAAM, B;MITCHELL, KD;NAVAR, LG
通讯作者：
NAVAR, LG