Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan.
Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan.
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DOI：
10.1038/s41598-021-85485-y
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发表时间：
2021-03-18
影响因子：
4.6
通讯作者：
Volpicelli G
中科院分区：
文献类型：
--
作者：
Ginsburg AS;Nisar I;Madrid L;Lenahan JL;Balouch B;Vitorino P;Hwang J;Lamorte A;Kanth N;Bila R;Valente M;Varo R;May S;Bassat Q;Jehan F;Volpicelli G
肺部超声(Lus)是诊断和治疗肺炎的一种很有前途的临床点成像技术。我们试图探索在资源有限的情况下对胸部吸入性肺炎的儿童进行一系列的lus检查，并纵向比较他们的临床和lus成像过程。我们在莫桑比克和巴基斯坦的两家地区医院进行了一项前瞻性、观察性研究，对象是患有世界卫生组织儿童疾病综合管理的2至23个月的儿童胸部吸入性肺炎，以及没有呼吸急促、胸部内陷或发烧(没有肺炎队列)的儿童。我们在登记时、第2天、第6天和第14天评估连续逻辑单元，并对登记的儿童的纵向临床和影像课程进行二次分析。到第14天，大多数患有吸入性肺炎和登记巩固的儿童的随访LU有所改善(莫桑比克为100%，巴基斯坦为85.4%)，临床治愈(莫桑比克为100%，巴基斯坦为78.0%)。在我们的吸胸肺炎儿童队列中，LU成像通常反映临床病程；然而，尚不清楚LU序列将如何为非严重吸胸肺炎的常规治疗提供信息。
Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-constrained settings and compare their clinical and LUS imaging courses longitudinally. We conducted a prospective, observational study among children aged 2 through 23 months with World Health Organization Integrated Management of Childhood Illness chest-indrawing pneumonia and among children without fast breathing, chest indrawing or fever (no pneumonia cohort) at 2 district hospitals in Mozambique and Pakistan. We assessed serial LUS at enrollment, 2, 6, and 14 days, and performed a secondary analysis of enrolled children’s longitudinal clinical and imaging courses. By Day 14, the majority of children with chest-indrawing pneumonia and consolidation on enrollment LUS showed improvement on follow-up LUS (100% in Mozambique, 85.4% in Pakistan) and were clinically cured (100% in Mozambique, 78.0% in Pakistan). In our cohort of children with chest-indrawing pneumonia, LUS imaging often reflected the clinical course; however, it is unclear how serial LUS would inform the routine management of non-severe chest-indrawing pneumonia.
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影响因子：
3.1
作者：
Ginsburg AS;Lenahan JL;Jehan F;Bila R;Lamorte A;Hwang J;Madrid L;Nisar MI;Vitorino P;Kanth N;Balcells R;Baloch B;May S;Valente M;Varo R;Nadeem N;Bassat Q;Volpicelli G
通讯作者：
Volpicelli G
影响因子：
2.3
作者：
Stadler, Jacob A. M.;Andronikou, Savvas;Zar, Heather J.
通讯作者：
Zar, Heather J.
影响因子：
3.6
作者：
Caiulo, Vito Antonio;Gargani, Luna;Picano, Eugenio
通讯作者：
Picano, Eugenio
影响因子：
4.3
作者：
Urbankowska, Emilia;Krenke, Katarzyna;Kulus, Marek
通讯作者：
Kulus, Marek
影响因子：
2.7
作者：
D'Amato, Maria;Rea, Gaetano;Sperandeo, Marco
通讯作者：
Sperandeo, Marco