Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer
Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer
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DOI：
10.1016/j.jmmm.2005.02.061
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Ross, BD
中科院分区：
文献类型：
--
作者：
Kopelman, R;Koo, YEL;Ross, BD
建立了脑癌检测、治疗和监测的范例。含有光敏剂的多功能生物医学纳米粒子（30-60nm）从外部向癌细胞输送活性氧（ROS），同时增强磁共振成像（MRI）对比度，提供实时肿瘤杀灭测量。实现血浆停留时间控制和特定细胞靶向。对大鼠进行 5 分钟的治疗后 3-4 天后，体内肿瘤生长停止甚至逆转。 (c) 2005 Elsevier B.V. 保留所有权利。
A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30-60nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5min treatment in rats halted and even reversed in vivo tumor growth after 3-4 days post-treatment. (c) 2005 Elsevier B.V. All rights reserved.