Optimal Design and Operation of Simulated Moving Bed Chromatographic Reactors
Optimal Design and Operation of Simulated Moving Bed Chromatographic Reactors
复制标题
模拟移动床色谱反应器的优化设计与操作
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
K. Klatt
中科院分区：
文献类型：
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作者：
G. Dünnebier;J. Fricke;K. Klatt
本文提出了一种新的模拟移动床（SMB）色谱过程优化设计策略，特别是SMB反应器。提出了一种合适的计算效率高、精度高的工艺模型。对SMB过程的建模和仿真进行了简要回顾，从而提出了过程模型的选择。回顾了SMB反应器的设计策略，它们的能力和局限性，这仅限于纯分离过程，因为迄今为止还没有针对SMB反应器的严格设计和优化方法发表。该优化策略基于数学优化、严格的动态过程模型和详细的成本函数。新的优化方法的期望性质是从目前已知的设计策略的局限性推导出来的。用SMB色谱反应器的两个应用实例说明了新方法的能力。可节省高达20%的运营成本。
This paper presents a novel optimization and design strategy for simulated moving bed (SMB) chromatographic processes in general and SMB reactors in particular. A suitable computationally efficient and accurate process model is presented. The choice of the process model is motivated by a brief review on modeling and simulation of SMB processes. A review on design strategies for SMB processes, their capabilities, and limitations is given, which is limited to pure separation processes since no rigorous design and optimization approach for SMB reactors has been published so far. The novel optimization strategy is based on mathematical optimization, a rigorous dynamic process model, and a detailed cost function. The desired properties of the novel optimization approach are derived from the limitations of the currently known design strategies. The capabilities of the new approach are illustrated using two applications of the SMB chromatographic reactor. Potential savings in operating cost of up to 20% and in d...