NFX1, Its Isoforms and Roles in Biology, Disease and Cancer.
NFX1, Its Isoforms and Roles in Biology, Disease and Cancer.
复制标题
DOI：
10.3390/biology10040279
复制
发表时间：
2021-03-30
期刊：
影响因子：
4.2
通讯作者：
Katzenellenbogen RA
中科院分区：
文献类型：
--
作者：
Chintala S;Katzenellenbogen RA
NFX1 基因及其基因产物于 30 多年前被发现。从那时起，关于 NFX1 同源物和 NFX1 本身的文献不断增多。在这篇综述中，我们总结了迄今为止跨物种和人类中 NFX1 基因及其蛋白质的研究，描述了它们在基因调控、胚胎发育、细胞生长和分化、外源应激耐受和代谢以及生物体免疫反应中的作用。我们还强调了 NFX1 在人类疾病和癌症中的作用，重点关注其与导致宫颈癌和头颈癌的高风险人乳头瘤病毒感染的协同作用。我们相信这是对 NFX1 及其在从酵母到人类等生物体中的功能意义的首次全面综述。 1989年，两种NFX1蛋白产物被鉴定为具有与X-box顺式元件结合能力的核蛋白。自该文章发表以来，从酵母到人类，NFX1 基因及其同源物均已被识别。这篇综述文章总结了跨物种 NFX1 基因的已知信息。我们描述了 NFX1 同源物的基因和蛋白质基序及其在细胞生物学中的功能，然后转向 NFX1 在人类生物学和疾病发展中的作用。其中，我们重点关注有关 NFX1 及其在上皮细胞中表达的两种剪接变体蛋白产物（NFX1-91 和 NFX1-123）的最新文献。我们描述了保守蛋白质基序、直接和间接基因表达调控以及关键蛋白质-蛋白质相互作用的新证据。最后，我们强调这些 NFX1 剪接变体在高危人乳头瘤病毒相关癌症中的新作用，以及在这些癌症中发现的较长剪接变体 NFX1-123 的表达增加。
The NFX1 gene, and its gene products, were identified over 30 years ago. Since then, the literature on NFX1 homologs and NFX1 itself has grown. In this review, we summarize the studies to-date on the NFX1 gene and its proteins across species and in humans, describing their role in gene regulation, embryonic development, cellular growth and differentiation, exogenous stress tolerance and metabolism, and an organism’s immune response. We also highlight the roles NFX1 has in human disease and in cancer, with a strong focus on its collaborative role with high-risk human papillomavirus infections that cause cervical and head and neck cancers. We believe this is the first comprehensive review of NFX1 and its functional significance in organisms ranging from yeast to human. In 1989, two NFX1 protein products were identified as nuclear proteins with the ability to bind to X-box cis-elements. Since that publication, the NFX1 gene and its homologs have been identified, from yeast to humans. This review article summarizes what is known about the NFX1 gene across species. We describe the gene and protein motifs of NFX1 homologs and their functions in cellular biology, then turn to NFX1 in human biology and disease development. In that, we focus on more recent literature about NFX1 and its two splice variants protein products (NFX1-91 and NFX1-123) that are expressed in epithelial cells. We describe new evidence of conserved protein motifs, direct and indirect gene expression regulation, and critical protein-protein interactions. Finally, we stress the emerging roles of these NFX1 splice variants in high-risk human papillomavirus-associated cancers, and the increased expression of the longer splice variant, NFX1-123, found in these cancers.
登录
查看更多内容
影响因子：
5.4
作者：
Katzenellenbogen, Rachel A.;Egelkrout, Erin M.;Galloway, Denise A.
通讯作者：
Galloway, Denise A.
影响因子：
5.4
作者：
Katzenellenbogen, Rachel A.;Vliet-Gregg, Portia;Galloway, Denise A.
通讯作者：
Galloway, Denise A.
影响因子：
10.5
作者：
Gewin, L;Myers, H;Galloway, DA
通讯作者：
Galloway, DA
DOI：
10.1016/j.jvir.2014.12.610
发表时间：
2015-05-01
影响因子：
2.9
作者：
Gaba, Ron C.;Groth, John V.;Casadaban, Leigh C.
通讯作者：
Casadaban, Leigh C.
影响因子：
4
作者：
Chintala, Sreenivasulu;Levan, Justine;Katzenellenbogen, Rachel A.
通讯作者：
Katzenellenbogen, Rachel A.