The role of peptide YY in regulating glucose homeostasis
The role of peptide YY in regulating glucose homeostasis
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DOI：
10.1016/j.peptides.2006.07.031
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发表时间：
2007-02-01
期刊：
影响因子：
3
通讯作者：
Herzog, Herbert
中科院分区：
文献类型：
--
作者：
Boey, Dana;Sainsbury, Amanda;Herzog, Herbert
肠道源性激素肽 YY (PYY) 因其对饱腹感的影响、减少动物和人类的食物摄入量和体重而闻名。然而，PYY 还参与广泛的消化功能，包括调节胰岛素分泌和葡萄糖稳态。在过去的几年里，有几项有趣的临床和动物研究调查了 PYY 在葡萄糖稳态中的作用。本综述旨在对过去几十年的研究结果进行更新总结，强调 PYY 在调节胰岛素输出和胰岛素敏感性中的作用以及所涉及的潜在机制。 (c) 2007 Elsevier Inc. 保留所有权利。
The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there have been several interesting clinical and animal studies investigating the role of PYY in glucose homeostasis. This review aims to present an updated summary of findings over the last few decades highlighting the role of PYY in regulating insulin output and insulin sensitivity, and the potential mechanisms involved. (c) 2007 Elsevier Inc. All rights reserved.