Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin
Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin
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DOI：
10.1080/080352502317371698
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发表时间：
2002-01-01
期刊：
影响因子：
3.8
通讯作者：
van de Bor, M
中科院分区：
文献类型：
--
作者：
Christmann, V;Liem, KD;van de Bor, M
推注吲哚美辛引起的血管收缩减少了器官灌注，并且与用于闭合动脉导管未闭（PDA）的吲哚美辛的众所周知的副作用有关。本研究的目的是比较大脑的变化。连续输注与推注吲哚美辛封堵PDA后的肾和肠系膜血流速度。32例PDA早产儿（胎龄26-35周）随机分为两组，分别接受相同剂量的吲哚美辛3次推注（n = 14）或连续输注（n = 18）36 h。在颈内动脉中测量血流速度。基线时和10时连续测量右肾动脉和上级肠系膜动脉。30. 60和120分钟和12. 24.开始吲哚美辛治疗后36和48 h。基线时两组之间的血流速度无差异。在持续输注吲哚美辛期间，脑、肾和肠系膜血流速度无显著变化。而接受推注的婴儿中的流速在吲哚美辛给药后的前2小时内在所有测量的动脉中显著降低。有一个短暂的。但推注吲哚美辛后尿量显著减少。持续输注吲哚美辛36 h以上不伴有器官血流量减少和尿量减少。
Vasoconstriction induced by bolus injection of indomethacin reduces organ perfusion and has been related to the well-known side effects of indomethacin given for closure of the patent ductus arteriosus (PDA). The aim of the Study was to compare the changes in cerebral. renal and mesenteric blood flow velocities after continuous infusion versus bolus injection of indomethacin for closure of the PDA. Thirty-two preterm infants (range 26-35 wk gestational age) with PDA were randomly assigned to receive the same amount of indomethacin either as three bolus injections (n = 14) or as a continuous infusion (n = 18) over 36 h. Blood flow velocities were measured in the internal carotid. right renal and superior mesenteric arteries at baseline and serially at 10. 30. 60 and 120 min and 12. 24. 36 and 48 h after the start of indomethacin treatment. There were no differences in blood flow velocities between both groups at baseline. During continuous infusion of indomethacin there was no significant change in the cerebral, renal and mesenteric blood flow velocities. whereas the flow, velocities in the infants receiving bolus injections decreased significantly during the first 2 h after indomethacin administration in all arteries measured. There was a transient. but significant reduction in urine Output after bolus injection of indomethacin.Conclusion: In contrast to bolus injections. decrease of organ blood flow and impairment of urine output do not accompany continuous infusion of indomethacin over 36 h.