The blood plasma ascorbic acid in patients with achlorhydria (pernicious and iron deficiency anemia)
The blood plasma ascorbic acid in patients with achlorhydria (pernicious and iron deficiency anemia)
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DOI：
10.1097/00000441-193902000-00010
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发表时间：
1939-02-01
影响因子：
3.1
通讯作者：
Farmer, CJ
中科院分区：
文献类型：
--
作者：
Alt, HL;Chinn, H;Farmer, CJ
文献中的证据表明，无氯血症可能是vit产生的一个诱发因素。C缺乏。Detns。测定了44例胃酸过少患者血浆中抗坏血酸的含量。该组主要由恶性贫血或慢性贫血缓解的患者组成。盐酸患者血浆中抗坏血酸的平均值为0.57[正负]0.02 mg. / 100 cc，显著低于24例对照患者的平均值0.79[正负]0.03 mg. / 100 cc。这种差异与饮食的变化无关。各种试验。提示无酸和吸收不良可以解释，至少部分，低血浆抗坏血酸在盐酸患者中观察到。
Evidence in the literature suggests that achlorhydria might be a pre-disposing factor in the production of vit. C deficiency. Detns. of the reduced ascorbic acid content of the plasma were made in 44 patients with achlorhydria. This group consisted largely of patients with pernicious anemia or achlorhydric anemia in remission. The mean value of 0.57 [plus or minus] 0.02 mg. ascorbic acid per 100 cc. plasma obtained in the achlorhydric patients was significantly lower than the mean value of 0.79 [plus or minus] 0.03 mg. per 100 cc. obtained in 24 control cases. This difference was not related to variations in the diet. Various expts. suggest that anacidity and malabsorption may explain, in part at least, the low plasma ascorbic acid observed in the achlorhydric patients.