Computer simulations of lung surfactant
Computer simulations of lung surfactant
复制标题
DOI：
10.1016/j.bbamem.2016.02.030
复制
发表时间：
2016-10-01
影响因子：
3.4
通讯作者：
Tieleman, D. Peter
中科院分区：
文献类型：
--
作者：
Baoukina, Svetlana;Tieleman, D. Peter
肺表面活性剂在肺中的气体交换界面上排列，并降低呼吸所必需的表面张力。肺表面活性物质主要由脂质和少量蛋白质组成，并在空气-水界面形成单层，连接到双层储库。肺表面活性物质的功能涉及在呼吸周期中单层和双层之间的物质转移。脂质和蛋白质在单层中横向组织;选定的物种可能优先转移到双层。肺表面活性物质复杂的三维结构以及脂质组织和蛋白质的确切作用仍然是研究的重要目标。我们回顾了最近的模拟研究的性质的脂质单分子膜，单分子膜与相共存，单层-双层转换，脂质-蛋白质的相互作用，和纳米粒子对肺surfactor.This文章的一部分，题为：生物模拟编辑Ilpo Vattulainen和Tomasz罗格。(C)© 2016 Elsevier B. V.版权所有。
Lung surfactant lines the gas-exchange interface in the lungs and reduces the surface tension, which is necessary for breathing. Lung surfactant consists mainly of lipids with a small amount of proteins and forms a monolayer at the air-water interface connected to bilayer reservoirs. Lung surfactant function involves transfer of material between the monolayer and bilayers during the breathing cycle. Lipids and proteins are organized laterally in the monolayer; selected species are possibly preferentially transferred to bilayers. The complex 3D structure of lung surfactant and the exact roles of lipid organization and proteins remain important goals for research. We review recent simulation studies on the properties of lipid monolayers, monolayers with phase coexistence, monolayer-bilayer transformations, lipid-protein interactions, and effects of nanoparticles on lung surfactant.This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Rog. (C) 2016 Elsevier B.V. All rights reserved.