Immunohistochemistry of adenosine deaminase: implications for adenosine neurotransmission.
Immunohistochemistry of adenosine deaminase: implications for adenosine neurotransmission.
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DOI：
10.1126/science.6142530
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发表时间：
1984-04
期刊：
影响因子：
56.9
通讯作者：
J. Nagy;L. LaBella;M. Buss;P. Daddona
中科院分区：
文献类型：
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作者：
J. Nagy;L. LaBella;M. Buss;P. Daddona
对大鼠大脑中腺苷脱氨酶的免疫组织化学分析显示，基底下丘脑中有广泛的含有腺苷脱氨酶的神经元丛。这些神经元聚集在三个主要中心，即结节、尾部和乳头后尾部大细胞核，并且数量最多。大多数其他大脑区域缺乏含有腺苷脱氨酶的细胞。当将染料注射到额叶皮层和纹状体时，一些含有腺苷脱氨酶的神经元被荧光染料固蓝逆行标记。具有高水平腺苷脱氨酶的特定神经元群体可以释放腺苷作为神经递质。
Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Most other brain regions were devoid of cells containing adenosine deaminase. Some adenosine deaminase-containing neurons were retrogradely labeled with the fluorescent dye fast blue when the dye was injected into the frontal cortex and striatum. Specific populations of neurons having high levels of adenosine deaminase may release adenosine as a neurotransmitter.