Reduction in erythrocyte complement receptor 1 (CR1,CD35) and decay accelerating factor (DAF,CD55) during normal pregnancy
Reduction in erythrocyte complement receptor 1 (CR1,CD35) and decay accelerating factor (DAF,CD55) during normal pregnancy
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DOI：
10.1016/0165-0378(96)00977-1
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发表时间：
1996-10-01
影响因子：
3.4
通讯作者：
Jones, DRE
中科院分区：
文献类型：
--
作者：
Imrie, HJ;McGonigle, TP;Jones, DRE
RBC-膜CR 1已在妊娠期和产后48小时测定。研究表明，RBC CR 1随着妊娠的进展而降低，在妊娠晚期达到最低点，并在产后48小时内恢复到接近正常的水平。此外，在妊娠期间，RBC衰变加速因子（RBC decay accelerating factor，CD 59）的表达减少，但RBC CD 59的表达没有变化。我们认为，RBC CR 1和CR2的减少可能反映了循环免疫复合物水平的增加，从而增加了妊娠期补体激活。
RBC-membrane CR1 has been assayed in pregnancy and at 48 h postpartum. It has been shown that RBC CR1 is reduced as pregnancy progresses, reaching a nadir in the third trimester and that it returns to levels approaching normal within 48 h postpartum. Further, there is a reduced expression of RBC decay accelerating factor (DAF) during pregnancy but no change in expression of RBC CD59. We Suggest that the reduction in RBC CR1 and DAF may reflect increased levels of circulating immune complexes and consequent increased complement activation in pregnancy.