Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression.
Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression.
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DOI：
10.1080/10401230600948399
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发表时间：
2006-10-01
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影响因子：
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通讯作者：
Philibert, Robert
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文献类型：
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作者：
Philibert, Robert
背景技术背景：人们普遍承认，绝大多数严重精神障碍都有明显的遗传因素，表现出复杂的遗传模式。尽管如此，很少有基因多态性被明确地确定为行为疾病的风险因素，并且这些选择的多态性影响人类行为的机制完全不清楚。这种缺乏进展的主要原因之一是基因-环境（GxE）相互作用的现象。METHODS：我们回顾了爱荷华州收养研究中GxE相互作用对重度抑郁症（MDD）的先前证据。RESULTS：结果证明了这些队列对MDD的直接G效应的有用性。CONCLUSIONS：我们的结论是，采用范式的进一步使用将产生关键的洞察候选基因的各种复杂的人类行为疾病的影响。
BACKGROUND: It is generally acknowledged that the vast majority of serious mental disorders have significant genetic contributions that manifest complex inheritance patterns. Despite this, few gene polymorphisms have been unambiguously identified as risk factors for behavioral illness and the mechanisms through which these select polymorphisms affect human behavior is completely unclear. One of the major reasons for this lack of progress is the phenomenon of gene-environment (GxE) interactions.METHODS: We review prior evidence of GxE interactions for major depressive disorder (MDD) in the Iowa Adoption Studies.RESULTS: The results demonstrate the usefulness of these cohorts to direct G effects for MDD.CONCLUSIONS: We conclude that further use of the adoption paradigm will generate critical insight into the effects of candidate genes for a variety of complex human behavioral illnesses.