Asymmetric β-Boration of α,β-Unsaturated Esters with Chiral (NHC)Cu Catalysts
Asymmetric β-Boration of α,β-Unsaturated Esters with Chiral (NHC)Cu Catalysts
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DOI：
10.1021/om800946k
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发表时间：
2009-01-26
期刊：
影响因子：
2.8
通讯作者：
Fernandez, Elena
中科院分区：
文献类型：
--
作者：
Lillo, Vanesa;Prieto, Auxiliadora;Fernandez, Elena
含有手性N-杂环卡宾配体的铜配合物催化区域选择性亲核硼基攻击α，β-不饱和酯的β-碳，对映选择性高达74%ee，这取决于酯基的性质。
Copper complexes containing chiral N-heterocyclic carbene ligands catalyze the regioselective nucleophilic boryl attack at the beta-carbon of alpha,beta-unsaturated esters with enantioselectivities up to 74% ee, depending on the nature of the ester group.