Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-beta superfamily, is expressed in the hindbrain and epibranchial placodes.
Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-beta superfamily, is expressed in the hindbrain and epibranchial placodes.
复制标题
Gdf16 是 TGF-β 超家族生长/分化因子亚组的新成员，在后脑和鳃上基板中表达。
DOI：
10.1016/s0925-4773(00)00350-6
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
Krieg,PA
中科院分区：
文献类型：
--
作者：
Vokes,SA;Krieg,PA
我们分离并鉴定了非洲爪哇Gdf16基因的发育表达，该基因是生长分化因子(GDF)基因家族的新成员。Gdf16基因编码413个氨基酸的前原蛋白和122个氨基酸的成熟肽。Gdf16与斑马鱼的发电机和雷达基因关系最为密切，但表现出完全不同的表达模式。在头两个鳃上胎盘的尾芽早期(阶段25)检测到基因表达，并在后脑特定的区域中检测到。随着发育的进行，该基因在所有鳃上安慰器、后脑和间脑中都有表达。
We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon.