MODELING THE CELL-DIVISION CYCLE - CDC2 AND CYCLIN INTERACTIONS
MODELING THE CELL-DIVISION CYCLE - CDC2 AND CYCLIN INTERACTIONS
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DOI：
10.1073/pnas.88.16.7328
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发表时间：
1991-08-01
影响因子：
11.1
通讯作者：
TYSON, JJ
中科院分区：
文献类型：
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作者：
TYSON, JJ
蛋白质 cdc2 和细胞周期蛋白形成异二聚体（成熟促进因子），控制细胞周期的主要事件。构建了 cdc2 和细胞周期蛋白相互作用的数学模型。模型的仿真和分析表明，控制系统可以在三种模式下运行：作为具有高成熟促进因子活性的稳态、作为自发振荡器或作为可兴奋开关。我们将稳态与未受精卵的中期停滞联系起来，将自发振荡与早期胚胎中的快速分裂周期联系起来，将兴奋开关与非胚胎细胞典型的生长控制分裂周期联系起来。
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.