Case control study on childhood leukemia in Lower Saxony, Germany - Basic considerations, methodology, and summary of results
Case control study on childhood leukemia in Lower Saxony, Germany - Basic considerations, methodology, and summary of results
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DOI：
10.1055/s-2008-1046470
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发表时间：
1996-07-01
影响因子：
1
通讯作者：
Michaelis, J
中科院分区：
文献类型：
--
作者：
Kaatsch, P;Kaletsch, U;Michaelis, J
在下萨克森州的两个城市观察到统计上有效的集群，这引起了极大的公众兴趣。成立了各种委员会，开展各种各样的实地调查。最后，决定在整个下萨克森州进行病例对照研究，以探索可能解释观察到的群集的潜在危险因素。选择数量有限的已经建立和目前讨论的假设进行调查。这项研究是基于在德国儿童癌症登记处（GCCR）登记的患者。对于1988年至1993年期间罹患白血病的每个儿童，选择了两个基于人群的对照（当地和州对照）和一个肿瘤对照。数据收集方式为家长自行填写问卷和电话访谈。此外，还对电磁场和氡进行了测量，并对儿童的出生记录进行了检查，目的是确认静脉注射维生素K预防与白血病或肿瘤之间的潜在联系。本文介绍了研究的概念和基本考虑、设计和统计评价。答复率和结果摘要也将被呈现。本文将作为后续出版物对具体潜在风险因素进行更详细分析的参考。425名患病儿童的父母和610名未患病儿童的父母被要求参与。患病儿童家庭的应答率为82%，未患病儿童家庭的应答率为71%。共有781名家长参与了这项研究。最重要的结果如下：Greaves的假设（9,10）得到以下结果的支持：在患白血病的儿童中，接种疫苗的频率较低，病毒相关感染的发生率较低，这些儿童更多的是头胎儿童，更频繁的是母乳喂养，他们可能在婴儿期与其他儿童接触较少。我们的数据没有显示肠外维生素K预防与白血病或肿瘤之间的显著关联（17）。
In two municipalities in Lower Saxony statistically valid clusters were observed, which attracted great public interest. Committees were set up to initiate a large variety of on-the-spot-investigations. Finally, it was decided to conduct a case control study throughout Lower Saxony to explore potential risk factors which might explain the observed clusters. A limited number of already established and currently discussed hypotheses was chosen for investigation.The study was based on patients registrated at the German Children's Cancer Registry (GCCR). For each child with leukemia diseased between 1988 and 1993 two population-based controls (local and state controls) and one tumour control were selected.Data were collected by means of a questionnaire self-administered by the parents and a telephone interview. In addition, measurements of electromagnetic fields and radon were performed and inspections of the child's birth record were made for the purpose of confirming a potential association between parenteral vitamin K prophylaxis and leukemia or tumours.This paper presents the concept and basic considerations of the study, its design and statistical evaluation. Response rates and a summary of results will be presented, too. The paper will serve as a reference for subsequent publications about more detailed analyses of specific potential risk factors.425 parents of diseased children and 610 of non-diseased children were asked for participation. The rates of response were 82% for families with diseased and 71% for families with non-diseased children. In total, 781 parents participated in the study. The most important results are as follows:The Greaves' hypothesis (9, 10) was supported by the following results: Tn children diseased with leukemia, vaccinations were less frequent, virus-related infections occurred more rarely, these children were more frequently first-born children and more frequently breast-feed, and they possibly had fewer contacts with other children in infancy.Our data do not show a significant association between parenteral vitamin K prophylaxis and leukemia or tumours (17).