A dual action of histamine on isolated human pulmonary arteries.
A dual action of histamine on isolated human pulmonary arteries.
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组胺对离体人肺动脉的双重作用。
DOI：
10.1159/000194261
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
B. Simonsson
中科院分区：
文献类型：
--
作者：
J. Boe;M. Boe;B. Simonsson
本文研究了17例胸外科患者22条离体肺段动脉在组胺刺激后的等长张力变化。构建了累积剂量-反应收缩曲线。H2拮抗剂西咪替丁对组胺有轻微的增强作用，而H1拮抗剂甲胺则使组胺的对数剂量反应曲线向右移动，表明组胺对特定受体具有竞争性拮抗作用。当用组胺进行最大收缩后加入新皮拉明时，松弛发生，在加入新皮拉明之前加入西咪替丁可以阻断松弛。体外实验揭示了组胺的双重作用，主要是H1受体介导的收缩，但也有可能通过特定的H2受体在人肺动脉中放松。
Isometric tension changes in 22 isolated segmental human pulmonary arteries obtained from 17 patients at thoracic surgery were studied after histamine challenge. Cumulative dose-response contraction curves were constructed. A slight potentiation could be found with the H2 antagonist cimetidine, whereas the H1 blocker mepyramine moved the log dose-response curve for histamine to the right indicating competitive antagonism at specific receptors. When mepyramine was added after maximal contraction with histamine, a relaxation occurred that could be blocked by adding cimetidine prior to mepyramine. The in vitro tests reveal a dual action of histamine with a dominating H1 receptor mediated contraction, but with the possibility of relaxation via specific H2 receptors in human pulmonary arteries.