Current state of the development of mesenchymal stem cells into clinically applicable Schwann cell transplants
Current state of the development of mesenchymal stem cells into clinically applicable Schwann cell transplants
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间充质干细胞发展为临床适用雪旺细胞移植的现状
DOI：
10.1007/s11010-012-1351-6
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发表时间：
2012-09-01
影响因子：
4.3
通讯作者：
Cai, Sa
中科院分区：
文献类型：
--
作者：
Pan, Yu;Cai, Sa
雪旺细胞对于周围神经系统损伤的恢复至关重要，中枢神经系统（CNS）中雪旺细胞的缺失可能是中枢神经系统再生能力的关键限制因素。人们已经研究了各种类型的干细胞被诱导形成雪旺细胞表型的潜力，其中间充质干细胞（MSC）是其中最有前途的。本综述详细介绍了诱导 MSC 分化为雪旺细胞样细胞的方法。本文特别讨论了与 MSC 成功分化为雪旺细胞样细胞相关的证据，包括形态、表型、功能和蛋白质组的变化。还提出了 MSC 分化为雪旺细胞样细胞的可能解释。最后，我们提出了未来需要实现的研究目标，以阐明施万细胞分化和间充质干细胞转分化的生物学特性，从而使治疗性分化间充质干细胞移植到神经损伤部位的临床应用成为可能。
Schwann cells are critically important in recovery from injuries to the peripheral nervous system, and their absence from the central nervous system (CNS) may be a critical limiting factor in the CNS regeneration capacity. Various types of stem cells have been investigated for their potential to be induced to develop a Schwann cell phenotype, with mesenchymal stem cells (MSCs) being the most promising among them. The methods for inducing MSCs differentiation into Schwann cell-like cells are presented in detail in this review. The evidence related to successful differentiation of MSCs to Schwann cell-like cells is particularly discussed herein, which includes the changes in morphology, phenotype, function, and proteome. The possible explanations for the differentiation of MSCs to Schwann cell-like cells are also presented. Finally, we suggest future research aims which will need to be fulfilled to elucidate the biology of Schwann cell differentiation and MSC transdifferentiation, to enable clinical application of therapeutic differentiated MSC transplantation into nerve injury sites.