Immune cell regulation by autocrine purinergic signalling.

Immune cell regulation by autocrine purinergic signalling.
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DOI:
10.1038/nri2938
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发表时间:
2011-03
期刊:
Nature reviews. Immunology
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嘌呤能信号调节广泛的细胞过程。几乎任何哺乳动物细胞类型的刺激导致细胞ATP的释放和通过各种不同的嘌呤能受体的自分泌反馈。根据所涉及的嘌呤能受体的类型,自分泌信号可以促进或抑制细胞活化并微调功能反应。最近的研究表明,自分泌信号是免疫细胞激活中的一个重要检查点,允许细胞根据其环境提供的细胞外信号调节其功能反应。
Purinergic signalling regulates a wide range of cellular processes. Stimulation of virtually any mammalian cell type leads to the release of cellular ATP and autocrine feedback through a diverse set of different purinergic receptors. Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune functional responses. Recent work has shown that autocrine signalling is an important checkpoint in immune cell activation that allows cells to adjust their functional responses based on extracellular cues provided by their environment.
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