Immune cell regulation by autocrine purinergic signalling.
Immune cell regulation by autocrine purinergic signalling.
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DOI:
10.1038/nri2938
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发表时间:
2011-03
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Purinergic signalling regulates a wide range of cellular processes. Stimulation of virtually any mammalian cell type leads to the release of cellular ATP and autocrine feedback through a diverse set of different purinergic receptors. Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune functional responses. Recent work has shown that autocrine signalling is an important checkpoint in immune cell activation that allows cells to adjust their functional responses based on extracellular cues provided by their environment.
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