THE INFLUENCE OF FETECTOMY AT MID-GESTATION UPON THE SERUM CONCENTRATIONS OF PROGESTERONE, ESTRONE, AND ESTRADIOL IN BABOONS
THE INFLUENCE OF FETECTOMY AT MID-GESTATION UPON THE SERUM CONCENTRATIONS OF PROGESTERONE, ESTRONE, AND ESTRADIOL IN BABOONS
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DOI：
10.1210/endo-107-3-766
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发表时间：
1980-01-01
期刊：
影响因子：
4.8
通讯作者：
PEPE, GJ
中科院分区：
文献类型：
--
作者：
ALBRECHT, ED;HASKINS, AL;PEPE, GJ
本研究测定了狒狒妊娠中期切除胎儿对外周血清孕酮（P）、雌酮（E1）和雌二醇（E2）浓度的影响。在妊娠90天至产后24小时期间，每隔1-4天采集5只狒狒（在妊娠100-109天取出胎儿但未取出胎盘）和4只未处理狒狒的母体隐静脉血。放射免疫法测定血清P、E1、E2浓度。在妊娠中期切除胎儿的狒狒在第169天自发分娩胎盘。8（平均值±）。（一）妊娠。狒狒群体的平均妊娠期为184天。胎儿切除导致血清P浓度显著下降（64-80%; P < 0.001），从胎儿切除前5只狒狒的平均值6.9-9.7 ng/ml下降到胎儿切除后的1.7-3.5 ng/ml。在妊娠90天和足月之间，SE）未处理狒狒的血清P浓度为7.7 ± 0.001。0.3 ng/ml，虽然P浓度值波动，但浓度没有显著的进行性上升或下降。血清E1和E2浓度迅速下降，平均值分别为0.38-0.75和0.8-3.2 ng/ml，胎儿切除术前非常低，在大多数情况下，检测不到的水平之后。未给药狒狒的血清E2浓度随妊娠进展而增加（P < 0.001），在近足月达到最大值6.4-12.8 ng/ml。在整个研究期间，未给药动物的血清E1浓度范围为0.20-2.00 ng/ml，这些水平未发生显著的进行性升高或降低。狒狒妊娠中期至晚期外周循环中P浓度升高和雌激素浓度逐渐升高，显然取决于胎儿的存在。
The influence of fetectomy at midgestation in baboons upon the peripheral serum concentrations of progesterone (P), estrone (E1) and estradiol (E2) was determined. Maternal saphenous venous blood was collected at 1-4 day intervals between 90 days gestation and the 24 h postpartum period in 5 baboons in whom the fetus but not the placenta was removed at 100-109 days gestation and in 4 untreated baboons. Serum P, E1 and E2 concentrations were determined by radioimmunoassay. Baboons fetectomized at midgestation spontaneously delivered their placentas on day 169 .+-. 8 (mean .+-. SE) of gestation. The mean length of gestation for the baboon colony is 184 days. Fetectomy resulted in a marked decline (64-80%; P < 0.001) in serum P concentrations from mean values of 6.9-9.7 ng/ml in the 5 baboons before fetectomy to 1.7-3.5 ng/ml thereafter. Between 90 days gestation and term the mean (.+-. SE) serum P concentration in untreated baboons was 7.7 .+-. 0.3 ng/ml, and although P concentrations fluctuated in value, no significant progressive rise or fall in concentrations occurred. Serum E1 and E2 concentrations rapidly decreased from mean values of 0.38-0.75 and 0.8-3.2 ng/ml, respectively, before fetectomy to very low and, in most cases, undetectable levels thereafter. Serum E2 concentrations in untreated baboons increased (P < 0.001) with progressing gestation, attaining maximum values of 6.4-12.8 ng/ml near term. Serum E1 concentrations in untreated animals ranged between 0.20-2.00 ng/ml throughout the study period and no significant progressive rise or fall in these levels occurred. The elevated concentrations of P and the progressive rise in the concentrations of estrogen in the peripheral circulation during mid to late gestation of the baboon apparently are dependent upon the presence of the fetus.