Urinary bladder cancer risk factors in Egypt: a multicenter case-control study.
Urinary bladder cancer risk factors in Egypt: a multicenter case-control study.
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DOI：
10.1158/1055-9965.epi-11-0589
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Loffredo CA
中科院分区：
文献类型：
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作者：
Zheng YL;Amr S;Saleh DA;Dash C;Ezzat S;Mikhail NN;Gouda I;Loay I;Hifnawy T;Abdel-Hamid M;Khaled H;Wolpert B;Abdel-Aziz MA;Loffredo CA
我们调查了烟草暴露、血吸虫病史和膀胱癌风险之间的关系。我们分析了来自病例对照研究的数据（1,886例新诊断和组织学确诊病例和2,716例年龄、性别和居住地匹配的以人群为基础的对照）。使用逻辑回归，我们估计协变量校正的优势比（OR）和95%置信区间（CI）的关联。在男性中，吸烟与尿路上皮癌（UC）的风险增加相关（OR = 1.8, 95% CI = 1.4, 2.2），但与鳞状细胞癌（SCC）无关；同时吸水烟和香烟与UC （OR = 2.9, 95% CI = 2.1, 3.9）和SCC （OR = 1.8, 95% CI = 1.2, 2.6）的更大风险相关。在不吸烟的男性和女性中，接触环境烟草烟雾与UC风险增加有关。血吸虫病史与女性UC （OR = 1.9, 95% CI = 1.2, 2.9）和SCC （OR = 1.9, 95% CI = 1.2, 3.0）的风险增加相关，而男性则在较小程度上（OR = 1.4, 95% CI = 1.2, 1.7和OR = 1.4, 95% CI = 1.1, 1.7，分别为UC和SCC）。结果表明，血吸虫病和吸烟增加SCC和UC的风险。这项研究为膀胱癌亚型与血吸虫病之间的关系提供了新的证据，并表明吸烟和水烟会增加埃及男性患SCC和UC的风险。
We investigated associations between tobacco exposure, history of schistosomiasis and bladder cancer risk in Egypt. We analyzed data from a case-control study (1,886 newly diagnosed and histologically confirmed cases and 2,716 age-, gender-, and residence-matched, population-based controls). Using logistic regression we estimated the covariate-adjusted odds ratios (OR) and 95% confidence interval (CI) of the associations. Among men, cigarette smoking was associated with an increased risk of urothelial carcinoma (UC) (OR = 1.8, 95% CI = 1.4, 2.2), but not squamous cell carcinoma (SCC); smoking both waterpipes and cigarettes was associated with an even greater risk for UC (OR = 2.9, 95% CI = 2.1, 3.9) and a statistically significant risk for SCC (OR = 1.8, 95% CI = 1.2, 2.6). Among non-smoking men and women, to environmental tobacco smoke exposure was associated with an increased risk of UC. History of schistosomiasis was associated with increased risk of both UC (OR = 1.9, 95% CI = 1.2, 2.9) and SCC (OR = 1.9, 95% CI = 1.2, 3.0) in women and to a lesser extent (OR = 1.4, 95% CI = 1.2, 1.7 and OR = 1.4, 95% CI = 1.1, 1.7, for UC and SCC respectively) in men. The results suggest that schistosomiasis and tobacco smoking increase the risk of both SCC and UC. This study provides new evidence for associations between bladder cancer subtypes and schistosomiasis, and suggests that smoking both cigarettes and waterpipes increases the risk for SCC and UC in Egyptian men.