Intermittent hypoxia in patients with unexplained polycythaemia.
Intermittent hypoxia in patients with unexplained polycythaemia.
复制标题
不明原因红细胞增多症患者的间歇性缺氧。
作者：
J. Moore;D. Treacher;E. Gaminara;T. Pearson;I. R. Cameron
多达30%的患者红细胞增多症的病因尚不清楚。对20例不明原因红细胞增多症患者进行了研究，以确定他们是否有间歇性缺氧刺激红细胞生成，而常规的缺氧继发性红细胞增多症检查未发现这种刺激。夜间多导睡眠研究显示，5名患者有长期夜间低氧血症。他们的动脉血氧饱和度低于92%，在这个水平上，红细胞生成的明显缺氧刺激发生，在他们被研究的时间的26-68%。越来越多的证据表明，间歇性缺氧是一种强有力的刺激红细胞生成，临床医生应考虑不明原因红细胞增多症患者夜间缺氧的可能性。适当的调查将导致正确诊断继发于缺氧的红细胞增多症，在一些情况下，以前被认为是特发性的，然后可以相应地计划治疗。
The aetiology of polycythaemia is unclear in up to 30% of patients. Twenty patients with unexplained polycythaemia were investigated to see whether they had an intermittent hypoxic stimulus to erythropoiesis that was undetected by conventional investigations for hypoxic secondary polycythaemia. Overnight polygraphic sleep studies showed that five patients had prolonged nocturnal hypoxaemia. Their arterial oxygen saturation was below 92%, the level at which appreciable hypoxic stimulation of erythropoiesis occurs, for 26-68% of the time for which they were studied. Considerable evidence is accumulating that intermittent hypoxia is a potent stimulus to erythropoiesis, and clinicians should consider the possibility of nocturnal hypoxia in patients with unexplained polycythaemia. Appropriate investigation will lead to the correct diagnosis of polycythaemia secondary to hypoxia in some cases previously regarded as idiopathic, and treatment may then be planned accordingly.