MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT
MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT
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DOI：
10.1037/h0077579
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
BARNES, CA
中科院分区：
文献类型：
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作者：
BARNES, CA
对32例老年人(28~34个月)进行了神经生理和行为测量。成熟成虫32只(10~16mo)老鼠。细胞外记录的突触反应是从长期植入齿状筋膜和穿支路径的电极获得的。大鼠首先在圆形平台上进行测试，这有利于使用空间线索来解决问题，而衰老的大鼠对奖励的地方表现出更差的记忆力。在一次非常短暂的高频刺激后记录颗粒细胞突触反应时，不同年龄组之间的升高量和下降的时间进程是相同的。然而，在重复3次后，年轻大鼠至少在14天内保持了增加的突触强度；老年大鼠在第一次训练后下降。突触增强的量与组内和组间执行环形平台任务的能力在统计学上相关。高频刺激的后遗症选择性地损害老年大鼠在T迷宫上的自发交替行为。其他一些神经生理学和脑电指标并没有区分不同的年龄段。讨论了记忆形成的突触理论及其与衰老过程的相关性也存在于人类中。
Neurophysiolgical and behavioral measures were obtained from 32 senescent (28-34 mo.) and 32 mature adult (10-16 mo.) rats. Extracellularly recorded synaptic responses were obtained from electrodes chronically implanted in the fascia dentata and perforant path. The rats were first tested on a circular platform, which favored the use of spatial cues for its solution, and the senescent rats exhibited poorer memory for the rewarded place. When granule cell synaptic responses were recorded after a single session of very brief, high-frequency stimulation, the amount of elevation and time course of decline were equivalent between age groups. After 3 repetitions, however, the young rats maintained the increased synaptic strength for at least 14 days; the old rats declined after the 1st session. The amount of synaptic enhancement was statistically correlated with the ability to perform the circular platform task both within and between groups. The aftereffects of the high-frequency stimulation selectively impaired the old rats'' spontaneous alternation behavior on a T-maze. Certain other neurophysiological and EEG measures did not distinguish between age groups. The synaptic theory of memory formation and of their relevance to the aging process also present in humans is discussed.