Voltage-responsive micelles based on the assembly of two biocompatible homopolymers
Voltage-responsive micelles based on the assembly of two biocompatible homopolymers
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基于两种生物相容性均聚物组装的电压响应胶束
DOI：
10.1039/c3py01204b
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发表时间：
2014-03-07
影响因子：
4.6
通讯作者：
Yuan, Jinying
中科院分区：
文献类型：
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作者：
Peng, Liao;Feng, Anchao;Yuan, Jinying
电压刺激法被认为是一种简便的刺激响应性聚合物体系的制备方法，其中基于β-环糊精（β-CD）和二茂铁（Fc）的体系受到了广泛的关注。在此，我们报告的电压响应胶束的基础上组装的两个生物相容性均聚物，即，聚（乙二醇）均聚物与β-CD（PEG-β-CD）和聚（L-丙交酯）均聚物与Fc（PLLA-Fc）改性。通过β-CD和Fc之间的主客体相互作用，两种均聚物连接在一起，形成非共价超分子嵌段共聚物PLLA Fc/PEG-beta-CD。PLLA Fc/PEG-β-CD在水溶液中可进一步自组装形成稳定的胶束。通过电化学控制，实现了该胶束体系的可逆组装-拆卸转变。并成功地进行了基于该体系的电压控制药物释放实验。
Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on beta-cyclodextrin (beta-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two biocompatible homopolymers, namely, the poly(ethylene glycol) homopolymer modified with beta-CD (PEG-beta-CD) and the poly(L-lactide) homopolymer modified with Fc (PLLA-Fc). Through host guest interactions between beta-CD and Fc, the two homopolymers connect together, forming a non-covalent supramolecular block copolymer PLLA Fc/PEG-beta-CD. PLLA Fc/PEG-beta-CD can further self-assemble to form stable micelles in aqueous solution. Through electrochemical control, a reversible assembly disassembly transition of this micellar system was realized. Voltage-controlled drug release based on this system was also conducted successfully.